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Titolo:
Role of heat shock protein HSP70-2 in spermatogenesis
Autore:
Eddy, EM;
Indirizzi:
NIEHS, Reprod & Dev Toxicol Lab, NIH, Res Triangle Pk, NC 27709 USA NIEHSRes Triangle Pk NC USA 27709 ab, NIH, Res Triangle Pk, NC 27709 USA
Titolo Testata:
REVIEWS OF REPRODUCTION
fascicolo: 1, volume: 4, anno: 1999,
pagine: 23 - 30
SICI:
1359-6004(199901)4:1<23:ROHSPH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTALLY-REGULATED EXPRESSION; GERM-CELL APOPTOSIS; GENE FAMILY; MOLECULAR CHAPERONES; RAT TESTIS; SYNAPTONEMAL COMPLEX; IMMOBILIZING PROTEIN; HSP70-RELATED GENE; CDC2 PROTEIN; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Eddy, EM NIEHS, Reprod & Dev Toxicol Lab, NIH, 111 TW Alexander Dr, Res Triangle Pk, NIEHS 111 TW Alexander Dr Res Triangle Pk NC USA 27709 iangle Pk,
Citazione:
E.M. Eddy, "Role of heat shock protein HSP70-2 in spermatogenesis", REV REPROD, 4(1), 1999, pp. 23-30

Abstract

The HSP70 heat-shock proteins are molecular chaperones that assist other proteins in their folding, transport and assembly into complexes. Most of these proteins are either constitutively expressed or their expression is induced by heat shock and other stresses. However, two members of the Hsp70 family (HSP70-2 and HSC70T in mice) are regulated developmentally and expressed specifically in spermatogenic cells. The HSP70-2 protein is synthesized during the meiotic phase of spermatogenesis and is abundant in pachytene spermatocytes. The knockout approach was used to determine whether HSP70-2 isa chaperone for proteins involved in meiosis. Male mice lacking HSP70-2 were infertile while females lacking HSP70-2 were fertile. Spermatogenic celldevelopment was arrested in prophase of meiosis I at the G2-M-phase transition and late pachytene spermatocytes were eliminated by apoptosis, resulting in an absence of spermatids. HSP70-2 is required for Cdc2 to form a heterodimer with cyclin B1, suggesting that it is a chaperone necessary for theprogression of meiosis in the germ cells of male mice. HSP70-2 is also associated with the synaptonemal complex and desynapsis is disrupted in male mice lacking this protein. Homologues of HSP70-2 are present in the testes of many animals, suggesting that the role of this spermatogenic cell chaperone is conserved across phyla.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:26:07