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Titolo:
Suspected non-small cell lung cancer: Incidence of occult brain and skeletal metastases and effectiveness of imaging for detection - Pilot study
Autore:
Earnest, F; Ryu, JH; Miller, GM; Luetmer, PH; Forstrom, LA; Burnett, OL; Rowland, CM; Swensen, SJ; Midthun, DE;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Diagnost Radiol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 diol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Pulm & Crit Care Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA Mayo Clin Jacksonville, Dept Diagnost Radiol, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 211, anno: 1999,
pagine: 137 - 145
SICI:
0033-8419(199904)211:1<137:SNCLCI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST-ENHANCED MR; BRONCHOGENIC-CARCINOMA; COMPUTED-TOMOGRAPHY; INTRACRANIAL METASTASES; CLINICAL-EVALUATION; ORGAN SCANS; CT; CHEST; TRIAL;
Keywords:
brain neoplasms, MR; brain neoplasms, secondary; clung neoplasms, staging; spine; spine, radionuclide studies; spine, secondary neoplasms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Earnest, F Mayo905in & Mayo Fdn, Dept Diagnost Radiol, 200 1st St SW, Rochester, MN 55 Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 MN 55
Citazione:
F. Earnest et al., "Suspected non-small cell lung cancer: Incidence of occult brain and skeletal metastases and effectiveness of imaging for detection - Pilot study", RADIOLOGY, 211(1), 1999, pp. 137-145

Abstract

PURPOSE: To estimate the incidence of occult metastases to the brain and skeleton in patients suspected of having non-small cell lung cancer (NSCLC)(stage higher than T1N0M0) with surgically resectable disease, to assess theaccuracy of screening magnetic resonance (MR) imaging and radionuclide bone scanning for help in identifying occult metastases, and to determine the effectiveness of a high dose of MR contrast material. MATERIALS AND METHODS: Twenty-nine patients suspected of having NSCLC localized to the lung or to the lung and regional nodes underwent preoperative MR imaging with contrast material enhancement and radionuclide bone scanning for detection of brain or skeletal metastases. Patients were followed up for 12 months to determine the incidence of clinical metastatic disease. RESULTS: Eight (28%) patients had occult metastatic disease to the brain or skeleton. Brain metastases were identified on MR images in five of six patients. Bone metastases were identified on MR images in four of five patients and on bone scans in three of five patients. MR imaging was no more accurate than bone scanning for skeletal evaluation. A high dose of MR contrastmaterial allowed detection of more metastases and of small lesions. CONCLUSION: Contrast-enhanced MR imaging of the brain is indicated for theexclusion of brain metastases in patients with clinically operable known or possible NSCLC and a large (>3-cm) lung mass. Skeletal imaging may be indicated if an isolated brain metastasis is detected.

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Documento generato il 05/12/20 alle ore 01:53:36