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Titolo:
Hypertrophic cardiomyopathy: MR measurement of coronary blood flow and vasodilator flow reserve in patients and healthy subjects
Autore:
Kawada, N; Sakuma, H; Yamakado, T; Takeda, K; Isaka, N; Nakano, T; Higgins, CB;
Indirizzi:
Mie Univ, Sch Med, Dept Radiol, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 Med, Dept Radiol, Tsu, Mie 5148507, Japan Mie Univ, Sch Med, Dept Internal Med, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 Dept Internal Med, Tsu, Mie 5148507, Japan Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 211, anno: 1999,
pagine: 129 - 135
SICI:
0033-8419(199904)211:1<129:HCMMOC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NONINVASIVE MEASUREMENT; ARTERY DISEASE; VELOCITY; QUANTIFICATION; PERFUSION; MYOCARDIUM; HUMANS;
Keywords:
coronary vessels, flow dynamics; coronary vessels, MR; heart, cardiomyopathy; heart, hypertrophy; myocardium, blood supply; myocardium, MR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kawada, N Mie Univ, Sch Med, Dept Radiol, 2 174 Edobashi, Tsu, Mie 5148507, Japan Mie Univ 2 174 Edobashi Tsu Mie Japan 5148507 Mie 5148507, Japan
Citazione:
N. Kawada et al., "Hypertrophic cardiomyopathy: MR measurement of coronary blood flow and vasodilator flow reserve in patients and healthy subjects", RADIOLOGY, 211(1), 1999, pp. 129-135

Abstract

PURPOSE: To evaluate coronary blood flow per gram of myocardial mass and vasodilator flow reserve in patients with hypertrophic cardiomyopathy (HCM) and in healthy subjects by using breath-hold velocity-encoded cine (VEC) magnetic resonance (MR) imaging. MATERIALS AND METHODS: Twenty-nine patients with HCM and nine healthy volunteers were examined. Fast VEC MR images were obtained in an oblique imaging plane perpendicular to the coronary sinus before and after intravenous injection of dipyridamole (0.56 mg/kg). The products of mean velocity and cross-sectional area of the vessel were integrated to measure blood flow. Breath-hold cine MR images encompassing the entire left ventricle were acquiredto quantify the left ventricular mass. RESULTS: In the basal state, the coronary blood flow per gram of myocardial mass was 0.74 mL/min/g +/- 0.23 in healthy subjects and 0.62 mL/min/g +/-0.27 in patients with HCM. After administration of dipyridamole, coronary blood Flow in patients with HCM increased to a level significantly less than that in healthy subjects (1.03 mL/min/g +/- 0.40 vs 2.14 mL/min/g +/- 0.51; P < .01), resulting in a severely depressed flow reserve ratio in patients with HCM compared with that in healthy subjects (1.72 +/- 0.49 vs 3.01 +/- 0.75; P < .01). CONCLUSION: Breath-hold VEC MR imaging is a noninvasive technique for evaluating coronary flow per gram of myocardial mass and coronary flow reserve.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:19:32