Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
An autopsy case of myotonic dystrophy with mental disorders and various neuropathologic features
Autore:
Mizukami, K; Sasaki, M; Baba, A; Suzuki, T; Shiraishi, H;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 1, volume: 53, anno: 1999,
pagine: 51 - 55
SICI:
1323-1316(199902)53:1<51:AACOMD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MRI FINDINGS; INVOLVEMENT; BRAIN;
Keywords:
mental disorders; myotonic dystrophy; neuropathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mizukami, K Univkisukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennoudai, Tsukuba, Ibara Univ Tsukuba 1-1-1 Tennoudai Tsukuba Ibaraki Japan 3058575 ara
Citazione:
K. Mizukami et al., "An autopsy case of myotonic dystrophy with mental disorders and various neuropathologic features", PSY CLIN N, 53(1), 1999, pp. 51-55

Abstract

An autopsy case of myotonic dystrophy (MD) is reported. The patient was a 58-year-old male. He presented with muscular weakness and muscular atrophy at the age of 33 and was diagnosed as having MD from myotonic symptoms (i.e. percussion and grip myotonia) at 49 years old. Mental disorders includinga delusional hallucinatory state, mental slowness, indifference, and lack of spontaneity as well as visual cognitive impairments were noted at the age of 55. He showed Parkinsonism and died of septic shock. T2-weighted magnetic resonance imaging demonstrated diffuse cortical atrophy with a marked frontal atrophy and high-intensity signals in the white matter. Single photon emission computed tomography demonstrated hypoperfusion in the frontal cortex. Neuropathologic observation revealed neuronal loss in the superficiallayer of the frontal and parietal cortices and extensive neuronal loss in the occipital cortex, intracytoplasmic inclusion body in the nerve cell of the medial thalamic nuclei, neuronal loss and presence of Lewy bodies in the substantia nigra and locus ceruleus corresponding to the pathologic features of Parkinson's disease, as well as abnormalities of myelin in the whitematter. The present case suggests that in MD brain, various neuropathologic changes may occur and they contribute to the mental disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:25:40