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Titolo:
Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs
Autore:
Baptista, T; Alvarez, L; Lacruz, A; De Mendoza, S; Hernandez, L;
Indirizzi:
Univ Los Andes, Sch Med, Dept Physiol & Psychiat, Merida, Venezuela Univ Los Andes Merida Venezuela t Physiol & Psychiat, Merida, Venezuela Metab Ctr, Merida, Venezuela Metab Ctr Merida VenezuelaMetab Ctr, Merida, Venezuela
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 23, anno: 1999,
pagine: 277 - 287
SICI:
0278-5846(199902)23:2<277:GTASIL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-WEIGHT GAIN; FEMALE RATS; LATERAL HYPOTHALAMUS; SYSTEMIC SULPIRIDE; HYPERPROLACTINEMIA; ENDOCRINE; AMANTADINE; MECHANISM; ESTROGEN;
Keywords:
antipsychotic drugs; glucose; insulin sensitivity; obesity; prolactin; rats;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Baptista, T Apartado 93, Merida 5101A, Venezuela Apartado 93 Merida Venezuela 5101A , Merida 5101A, Venezuela
Citazione:
T. Baptista et al., "Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs", PROG NEUR-P, 23(2), 1999, pp. 277-287

Abstract

1. To assess the role of insulin in the development of the obesity inducedby antipsychotic drugs, a glucose tolerance test was conducted in female rats after 10 or 30 days of sulpiride administration.2. At day 10, the area under the glucose curve did not differ between sulpiride and vehicle-treated rats, however, the area under the insulin curve was significantly decreased by sulpiride. At day, 30 the insulin response was similar in both groups, but the area under the glucose curve was significantly lower in the sulpiride-treated rats.3. The results suggest that insulin resistance and hyperinsulinemia are not involved in the development and maintenance of the obesity induced by sulpiride. Contrarily, these findings may be related to an increased insulin sensitivity.4. The absence of hyperinsulinemia and insulin resistance indicates important differences between primary obesity in humans and rodents and this model of drug-induced excessive weight gain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:57:35