Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin
Autore:
Lee-Huang, S; Huang, PL; Sun, YT; Huang, PL; Kung, HF; Blithe, DL; Chen, HC;
Indirizzi:
NYU, Sch Med, Dept Biochem, New York, NY 10016 USA NYU New York NY USA 10016 , Sch Med, Dept Biochem, New York, NY 10016 USA Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Dept Med, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 vard Univ, Sch Med, Boston, MA 02114 USA Harvard Community Hlth Plan, Boston, MA 02114 USA Harvard Community Hlth Plan Boston MA USA 02114 lan, Boston, MA 02114 USA NCI, Frederick Canc Res & Dev Ctr, Lab Biochem Physiol, Frederick, MD 21701 NCI Frederick MD USA 21701 Ctr, Lab Biochem Physiol, Frederick, MD 21701 NICHHD, Contracept & Reprod Hlth Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 rod Hlth Branch, NIH, Bethesda, MD 20892 USA NICHHD, Endocrinol & Reprod Res Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 prod Res Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 6, volume: 96, anno: 1999,
pagine: 2678 - 2681
SICI:
0027-8424(19990316)96:6<2678:LARAAC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA CELL-LINE; KAPOSIS-SARCOMA; RIBONUCLEASE; HORMONE; FRAGMENT; GROWTH; URINE; MICE;
Keywords:
AIDS; muramidase; urinary proteins; antiviral agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, HC NYU, Sch Med, Dept Biochem, New York, NY 10016 USA NYU New York NY USA 10016 , Dept Biochem, New York, NY 10016 USA
Citazione:
S. Lee-Huang et al., "Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin", P NAS US, 96(6), 1999, pp. 2678-2681

Abstract

Human chorionic gonadotropin (hCG) preparations contain activity against HIT: type 1 (HIV-1). However, there has been controversy about whether some biological activities of hCG beta-subunit (hCG beta) preparations are caused by the beta-subunit itself or other proteins present in the preparations,We report here the purification, characterization, and identification of three enzymes with anti-HIV activity present in the beta-core fraction of hCG beta prepared from the urine of pregnant women. The N-terminal amino acidsequence of one protein is identical to human urinary lysozyme C, and those of the other two are identical to human RNase A and urinary RNase U. We thus refer to these proteins as AVL (antiviral lysozyme) and AVR (antiviral RNases). In addition to HIV-1 inhibition, AVL is capable of lysing Micrococcus lysodeikticus. AVR digests a variety of RNA substrates, including RNA from HIV-1-infected cells. We also find that lysozyme from chicken egg white, human milk and human neutrophils and RNase A from bovine pancreas possessactivity against HIV-I. These findings may offer additional strategies forthe treatment of HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:20:49