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Titolo:
Temperature effects on the chromatographic behaviour of racemic 2-amidotetralins on a Whelk-O 1 stationary phase in super- and subcritical fluid chromatography
Autore:
Selditz, U; Copinga, S; Grol, CJ; Franke, JP; de Zeeuw, RA; Wikstrom, H; Gyllenhaal, O;
Indirizzi:
Statelytiv Groningen, Univ Ctr Pharm, Groningen Inst Drug Studies, Dept Ana State Univ Groningen Groningen Netherlands NL-9713 AV Studies, Dept Ana State Univ Groningen, Univ Ctr Pharm, Groningen Inst Drug Studies, Dept Med State Univ Groningen Groningen Netherlands NL-9713 AV Studies, Dept Med Astra Arcus, Preclin Res & Dev, Sodertalje, Sweden Astra Arcus Sodertalje Sweden us, Preclin Res & Dev, Sodertalje, Sweden Astra Hassle AB, Div Analyt Chem, Molndal, Sweden Astra Hassle AB Molndal Sweden sle AB, Div Analyt Chem, Molndal, Sweden
Titolo Testata:
PHARMAZIE
fascicolo: 3, volume: 54, anno: 1999,
pagine: 183 - 191
SICI:
0031-7144(199903)54:3<183:TEOTCB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRIVEN CHIRAL SEPARATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: de Zeeuw, RA Statelytivdsroningen, Univ Ctr Pharm, Groningen Inst Drug Studies, Dept Ana State Univ Groningen Antonius Deusinglaan 1 Groningen Netherlands NL-9713 AV
Citazione:
U. Selditz et al., "Temperature effects on the chromatographic behaviour of racemic 2-amidotetralins on a Whelk-O 1 stationary phase in super- and subcritical fluid chromatography", PHARMAZIE, 54(3), 1999, pp. 183-191

Abstract

The chromatographic behaviour of thirty structurally related racemic 2-amidotetralins on a cis-(3R, 4S)-Whelk-O 1 stationary phase was investigated at five different temperatures between 50 and -15 degrees C using super- or subscritical fluid chromatography (SFC/SubFC). Generally, low selectivity factors were observed for this class of analytes on this stationary phase. In particular, phenyl and benzyl substituted analogues were strongly retained, probably due to strong pi-pi interactions with the chiral selector molecule, but the enantioselectivity was low. This also counts for the two p-iodo substituted methoxy analogues, although here steric effects may be responsible for the high capacity factors. In about 10% of the cases, a decrease in the (surrounding) temperature of the column did not result in an improved selectivity. Only four compounds out of thirty could not be resolved under the given conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 23:40:30