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Titolo:
Medial septal and median raphe innervation of vasoactive intestinal polypeptide-containing interneurons in the hippocampus
Autore:
Papp, EC; Hajos, N; Acsady, L; Freund, TF;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 90, anno: 1999,
pagine: 369 - 382
SICI:
0306-4522(199905)90:2<369:MSAMRI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINE-ACETYLTRANSFERASE IMMUNOCYTOCHEMISTRY; SUBSTANCE-P RECEPTOR; RAT DENTATE GYRUS; THETA-RHYTHM; IMMUNOREACTIVE INTERNEURONS; INHIBITORY INTERNEURONS; CONTAINING NEURONS; PYRAMIDAL NEURONS; CEREBRAL-CORTEX; SEROTONIN INNERVATION;
Keywords:
VIP; median raphe; medial septum; serotonin; interneuron; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Freund, TF Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 est, Hungary
Citazione:
E.C. Papp et al., "Medial septal and median raphe innervation of vasoactive intestinal polypeptide-containing interneurons in the hippocampus", NEUROSCIENC, 90(2), 1999, pp. 369-382

Abstract

Vasoactive intestinal polypeptide-immunoreactive interneurons are known toform three anatomically and neurochemically well-characterized neuron populations in the hippocampus. Two of these establish synaptic contacts selectively with other GABAergic cells (interneuron-selective cells), whereas thethird type innervates pyramidal cell bodies and proximal dendrites like a conventional basket cell. Our aim was to examine which of the vasoactive intestinal polypeptide-containing interneuron populations are among the targets of GABAergic septohippocampal and serotonergic raphe-hippocampal pathways. Anterograde tracing with Phaseolus vulgar is leucoagglutinin combined with double immunocytochemistry for vasoactive intestinal polypeptide was used at the light and electron microscopic levels. Our results show that both interneuron-selective cells and vasoactive intestinal polypeptide-containing basket cells receive synaptic input from the medial septum and median raphe nucleus. The GABAergic component of the septohippocampal pathway establishes multiple contacts on both cell types. In the case of the raphe-hippocampal projection, single or double contacts were more frequent on vasoactiveintestinal polypeptide-positive interneuron selective cells (76%), whereasmultiple contacts predominated on basket cells (83%). The extrinsic GABAergic innervation of interneuron-selective cells in the hippocampus indicates a complex interaction among GABAergic systems, which might ensure the timing and rhythmic synchronization of inhibitory processes in the hippocampus. On the other hand, our results suggest that the serotonergic effect on perisomatic inhibition is exerted via vasoactive intestinal polypeptide-containing basket cells that are functionally distinct from their parvalbumin-positive relatives, which appear to escape control of serotonergic as well as local interneuron-selective cells. (C) 1999 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:04:04