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Titolo:
The first oncogene in Drosophila melanogaster
Autore:
Baek, KH;
Indirizzi:
Harvard02115, Sch Med, Dana Farber Canc Inst, Div Pediat Oncol, Boston, MAHarvard Univ Boston MA USA 02115 Canc Inst, Div Pediat Oncol, Boston, MA
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 2, volume: 436, anno: 1999,
pagine: 131 - 136
SICI:
1383-5742(199903)436:2<131:TFOIDM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; CELL-ADHESION MOLECULE; LETHAL(2)GIANT LARVAE LGL; II HEAVY-CHAIN; MALIGNANT NEOPLASMS; RECESSIVE ONCOGENE; MOUSE HOMOLOG; L(2)GL GENE; PROTEIN; CANCER;
Keywords:
Drosophila; oncogene; lethal (2) giant larvae; cadherin; mgl-1; hugl;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Baek, KH Harvardt,niv, Sch Med, Dana Farber Canc Inst, Div Pediat Oncol, 44 Binney S Harvard Univ 44 Binney St Boston MA USA 02115 Oncol, 44 Binney S
Citazione:
K.H. Baek, "The first oncogene in Drosophila melanogaster", MUT RES-R M, 436(2), 1999, pp. 131-136

Abstract

Discovered by Bridges in the 1930s, lethal (2) giant larvae was the first of more than 27 recessive oncogenes identified in Drosophila, which provides an excellent model to study neoplastic mechanisms due to the fact that homologs of human oncogenes and tumor suppressors have been isolated and mostof the complexes and associated pathways are conserved. This review explores the potential of neoplastic studies in Drosophila to help understand thegenomic mechanisms of neoplastic development in vertebrates and invertebrates. Starting from neoplasms and genetic mutations, the article introduces the reader to one of the possibilities that the studies on neoplastic mechanisms of oncogenes in Drosophila can provide a great understanding of the developmental progression in both vertebrates and invertebrates. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:11:30