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Titolo:
Measurement of human myocardial perfusion by double-gated flow alternatinginversion recovery EPI
Autore:
Poncelet, BP; Koelling, TM; Schmidt, CJ; Kwong, KK; Reese, TG; Ledden, P; Kantor, HL; Brady, TJ; Weisskoff, RM;
Indirizzi:
Massachusetts Gen Hosp, NMR Ctr, Charlestown, MA 02129 USA Massachusetts Gen Hosp Charlestown MA USA 02129 Charlestown, MA 02129 USA Massachusetts Gen Hosp, Cardiac Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 iac Unit, Boston, MA 02114 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 41, anno: 1999,
pagine: 510 - 519
SICI:
0740-3194(199903)41:3<510:MOHMPB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY MR-ANGIOGRAPHY; BLOOD-FLOW; MAGNETIC-RESONANCE; ARTERIAL WATER; SPIN INVERSION; RELAXATION-TIMES; GD-DTPA; 1.5 T; HEART; QUANTIFICATION;
Keywords:
heart; myocardial perfusion; arterial spin labeling; echoplanar imaging (EPI); human; swine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Poncelet, BP Massachusetts129n Hosp, NMR Ctr, CNY-2,Bldg 149,13th St, Charlestown, MA 02 Massachusetts Gen Hosp CNY-2,Bldg 149,13th St Charlestown MAUSA 02129
Citazione:
B.P. Poncelet et al., "Measurement of human myocardial perfusion by double-gated flow alternatinginversion recovery EPI", MAGN RES M, 41(3), 1999, pp. 510-519

Abstract

This paper presents a flow-sensitive alternating inversion recovery (FAIR)method for measuring human myocardial perfusion at 1.5 T. Slice-selectivelnon-selecfive IR images were collected using a double-gated IR echoplanar imaging sequence. Myocardial perfusion was calculated after T1 fitting and extrapolation of the mean signal difference SISel - SINSel. The accuracy of the method was tested in a porcine model using graded intravenous adenosinedose challenge. Comparison with radiolabeled microsphere measurements showed a good correlation (r = 0.84; mean error = 20%, n = 6) over the range offlows tested (0.9-7 ml/g/min). Applied in humans, this method allowed for the measurement of resting myocardial flow (1.04 +/- 0.37 ml/g/min, n = 11). The noise in our human measurements (SEflow = 0.2 ml/g/min) appears to come primarily from residual respiratory motion. Although the current signal-to-noise ratio limits our ability to measure small fluctuations in resting flow accurately the results indicate that this noninvasive method has greatpromise for the quantitative assessment of myocardial flow reserve in humans. Magn Reson Med 41:510-519, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:33:52