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Titolo:
Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats
Autore:
Sullivan, RM; Gratton, A;
Indirizzi:
McGilldaniv, Douglas Hosp, Res Ctr, Dept Psychiat, Verdun, PQ H4H 1R3, Cana McGill Univ Verdun PQ Canada H4H 1R3 t Psychiat, Verdun, PQ H4H 1R3, Cana
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 19, anno: 1999,
pagine: 2834 - 2840
SICI:
0270-6474(19990401)19:7<2834:LEOMPC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; FRONTAL-CORTEX; DOPAMINE DEPLETION; RESTRAINT STRESS; NERVOUS-SYSTEM; BRAIN-STEM; ASYMMETRY; ACTIVATION; PATHOLOGY; 6-HYDROXYDOPAMINE;
Keywords:
prefrontal cortex; asymmetry; ibotenic acid; stress ulcers; corticosterone; HPA axis; clinical depression; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Sullivan, RM McGilln,niv, Douglas Hosp, Res Ctr, Dept Psychiat, 6875 LaSalle Blvd, Verdu McGill Univ 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 Verdu
Citazione:
R.M. Sullivan e A. Gratton, "Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats", J NEUROSC, 19(7), 1999, pp. 2834-2840

Abstract

The medial prefrontal cortex (mPFC) is highly activated by stress and modulates neuroendocrine and autonomic function. Dopaminergic inputs to mPFC facilitate coping ability and demonstrate considerable hemispheric functionallateralization. The present study investigated the potentially lateralizedregulation of stress responses at the level of mPFC output neurons, using ibotenic acid lesions. Neuroendocrine function was assessed by plasma corticosterone increases in response to acute or repeated 20 min restraint stress. The primary index of autonomic activation was gastric ulcer development during a separate cold restraint stress. Restraint-induced defecation was also monitored. Plasma corticosterone levels were markedly lower in responseto repeated versus acute restraint stress. In acutely restrained animals, right or bilateral, but not left mPFC lesions, decreased prestress corticosterone levels, whereas in repeatedly restrained rats, the same lesions significantly reduced the peak stress-induced corticosterone response. Stress ulcer development (after a single cold restraint stress) was greatly reducedby either right or bilateral mPFC lesions but was unaffected by left lesions. Restraint-induced defecation was elevated in animals with left mPFC lesions. Finally, a left biased asymmetry in adrenal gland weights was observed across animals, which was unaffected by mPFC lesions. The results suggestthat mPFC output neurons demonstrate an intrinsic right brain specialization in both neuroendocrine and autonomic activation. Such findings may be particularly relevant to clinical depression which is associated with both disturbances in stress regulatory systems and hemispheric imbalances in prefrontal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:37:01