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Titolo:
A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression
Autore:
Calabresi, P; Gubellini, P; Centonze, D; Sancesario, G; Morello, M; Giorgi, M; Pisani, A; Bernardi, G;
Indirizzi:
Univalyma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, It Univ Roma Tor Vergata Rome Italy I-00133 , Neurol Clin, I-00133 Rome, It CNR, Ist Med Sperimentale, I-00133 Rome, Italy CNR Rome Italy I-00133CNR, Ist Med Sperimentale, I-00133 Rome, Italy Univ Aquila, Dipartimento Biol Base & Applicata, I-67010 Laquila, Italy Univ Aquila Laquila Italy I-67010 se & Applicata, I-67010 Laquila, Italy IRCCS, Osped S Lucia, I-00179 Rome, Italy IRCCS Rome Italy I-00179IRCCS, Osped S Lucia, I-00179 Rome, Italy
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 19, anno: 1999,
pagine: 2489 - 2499
SICI:
0270-6474(19990401)19:7<2489:ACROTN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; RAT STRIATAL NEURONS; CEREBELLAR PURKINJE NEURONS; SENSITIVE GUANYLYL CYCLASE; SYNAPTIC DEPRESSION; BASAL GANGLIA; SELECTIVE INHIBITORS; HIPPOCAMPAL SLICES; NERVOUS-SYSTEM; POTENTIATION;
Keywords:
intracellular recordings; electron microscopy; nitric oxide synthase; calmodulin-dependent phosphodiesterases; striatum; zaprinast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Gubellini, P Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata, Univ Roma Tor Vergata Via Tor Vergata Rome Italy I-00133 ta,
Citazione:
P. Calabresi et al., "A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression", J NEUROSC, 19(7), 1999, pp. 2489-2499

Abstract

High-frequency stimulation (HFS) of corticostriatal glutamatergic fibers induces long-term depression (LTD) of excitatory synaptic potentials recorded from striatal spiny neurons. This form of LTD can be mimicked by zaprinast, a selective inhibitor of cGMP phosphodiesterases (PDEs). Biochemical analysis shows that most of the striatal cGMP PDE activity is calmodulin-dependent and inhibited by zaprinast. The zaprinast-induced LTD occludes furtherdepression by tetanic stimulation and vice versa. Both forms of synaptic plasticity are blocked by intracellular 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a selective inhibitor of soluble guanylyl cyclase, indicating that an increased cGMP production in the spiny neuron is a key step. Accordingly, intracellular cGMP, activating protein kinase G (PKG), also induces LTD. Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP. LTD is also induced by the NO donors S-nitroso-N-acetylpenicillamine (SNAP)and hydroxylamine. SNAP-induced LTD occludes further depression by HFS or zaprinast, and it is blocked by intracellular ODQ but not by L-NAME Intracellular application of PKG inhibitors blocks LTD induced by HFS, zaprinast, and SNAP. Electron microscopy immunocytochemistry shows the presence of NOS-positive terminals of striatal interneurons forming synaptic contacts withdendrites of spiny neurons. These findings represent the first demonstration that the NO/cGMP pathway exerts a feed-forward control on the corticostriatal synaptic plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:26:52