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Titolo:
Enhancement of H-3-N-methylspiperone binding but not H-3-raclopride binding in mouse striatum by MK-801: evidence that factors other than competitionby endogenous dopamine are responsible for changes in D-2 receptor bindingin vivo
Autore:
Inoue, O; Wakahara, S; Kobayashi, K; Gee, A;
Indirizzi:
Osaka71,iv, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, Suita, Osaka 56508 Osaka Univ Suita Osaka Japan 5650871 i, Dept Med Phys, Suita, Osaka 56508 Aarhus Kommune Hosp, PET Ctr, DK-8000 Aarhus, Denmark Aarhus Kommune HospAarhus Denmark DK-8000 Ctr, DK-8000 Aarhus, Denmark
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 2, volume: 106, anno: 1999,
pagine: 131 - 137
SICI:
0300-9564(1999)106:2<131:EOHBBN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE; SEROTONERGIC MODULATION; H-3 RACLOPRIDE; HUMAN-BRAIN; INVIVO; PET;
Keywords:
raclopride; N-methylspiperone; MK-801; dopamine; receptors; vivo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, O Osakaita,v, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, 1-7 Yamada Oka, Su Osaka Univ 1-7 Yamada Oka Suita Osaka Japan 5650871 amada Oka, Su
Citazione:
O. Inoue et al., "Enhancement of H-3-N-methylspiperone binding but not H-3-raclopride binding in mouse striatum by MK-801: evidence that factors other than competitionby endogenous dopamine are responsible for changes in D-2 receptor bindingin vivo", J NEURAL TR, 106(2), 1999, pp. 131-137

Abstract

The effect of acute pretreatment with MK-801. on the binding in vivo of both H-3-N-methylspiperone (NMSP) and H-3-raclopride (RAC) were compared in mice. In the striatum, MK-801 significantly increase H-3-NMSP binding, whereas no significant alterations in H-3-RAC binding were seen. In contrast, binding in the cerebral cortex of both radiolabeled ligands was not changed by MK-801, Kinetic analysis revealed that the increase in H-3-NMSP binding induced by MK-801 was due to an increase in the rate constant k(3) (k(3) = k(on).B-max). In vivo saturation experiments showed that B-max for 3H-NMSP binding was relatively unchanged and an increase in the apparent associationrate constant (k(on)) was the main reason for an increase in the k(3) for H-3-NMSP binding. As H-3-RAC binding is known to be much more sensitive to competitive inhibition than is H-3-NMSP binding, these results strongly suggest that factors other than competition by endogenous dopamine may contribute to changes in receptor binding in vivo caused by NMDA-antagonism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:41:22