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Titolo:
Eicosanoids and membrane properties in arteries of aged spontaneously hypertensive rats
Autore:
Fujii, K; Onaka, U; Abe, I; Fujishima, M;
Indirizzi:
Kyushu Univ, Fac Med, Dept Internal Med 2, Higashi Ku, Fukuoka 81282, Japan Kyushu Univ Fukuoka Japan 81282 Med 2, Higashi Ku, Fukuoka 81282, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 1, volume: 17, anno: 1999,
pagine: 75 - 80
SICI:
0263-6352(199901)17:1<75:EAMPIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CALCIUM CHANNELS; THROMBOXANE-A2; ACETYLCHOLINE; AORTA; PROSTAGLANDIN-H2; CONTRACTION; DERIVATIVES;
Keywords:
membrane potential; spontaneous electrical activity; vascular smooth muscle cell; voltage-dependent Ca2+-channels; eicosanoids; aging; spontaneously hypertensive rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Fujishima, M Kyushuokaiv, Fac Med, Dept Internal Med 2, Higashi Ku, Maidashi 3-1-1, Fuku Kyushu Univ Maidashi 3-1-1 Fukuoka Japan 81282 i 3-1-1, Fuku
Citazione:
K. Fujii et al., "Eicosanoids and membrane properties in arteries of aged spontaneously hypertensive rats", J HYPERTENS, 17(1), 1999, pp. 75-80

Abstract

Objective The arteries of aged spontaneously hypertensive rats (SHR) exhibit spontaneous electrical activity together with membrane depolarization. Vascular eicosanoid production is increased in SHR, which is further accelerated with aging. We tested the hypothesis that eicosanoids are involved in spontaneous electrical activity, membrane depolarization or both in mesenteric arteries of aged SHR. Design and methods Membrane potentials were recorded with microelectrodes from the mesenteric arteries of aged (24 months and older) SHR, aged Wistar-Kyoto (WKY) rats and adult (6- to 8-month-old) SHR. Results The membrane potential was less negative in aged SHR (-38.5 +/- 0.9 mV) than in either aged WKY rats or adult SHR (-49.8 +/- 0.5 and -47.2 +/- 0.6 mV, respectively; P < 0.05 for both). Spontaneous electrical activity(5-20 mV, 1-7/min) was present only in arteries of aged SHR. Spontaneous electrical activity was not affected by phentolamine, atropine or tetrodotoxin, but was abolished by indomethacin, a cyclooxygenase inhibitor, and ONO-3708, a thromboxane A(2)/prostaglandin H-2 receptor antagonist. Furthermore, indomethacin and ONO-3708 hyperpolarized the membrane by about 5 mV in aged SHR but not in the other two groups. Spontaneous electrical activity wasenhanced by a thromboxane A(2) analog and prostaglandin H-2, and was abolished by a Ca2+ antagonist, nicardipine, and Ca2+-free solution. Conclusions These findings suggest that cyclooxygenase-dependent eicosanoids contribute importantly to both spontaneous electrical activity and membrane depolarization, presumably through activation of the thromboxane A(2)/prostaglandin H-2 receptor, in mesenteric arteries of aged SHR, and that spontaneous electrical activity is mediated by a Ca2+ influx through voltage-dependent Ca2+ channels. J Hypertens 1999; 17:75-80 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:46:02