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Titolo:
No linkage of the lipoprotein lipase locus to hypertension in Caucasians
Autore:
Hunt, SC; Province, MA; Atwood, LD; Sholinsky, P; Lalouel, JM; Rao, DC; Williams, RR; Leppert, MF;
Indirizzi:
Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84108 USA Univ Utah Salt Lake City UT USA 84108 l Med, Salt Lake City, UT 84108 USA Univ Utah, Dept Human Genet, Salt Lake City, UT 84108 USA Univ Utah Salt Lake City UT USA 84108 Genet, Salt Lake City, UT 84108 USA Univ Utah, Howard Hughes Med Inst, Salt Lake City, UT 84108 USA Univ UtahSalt Lake City UT USA 84108 Inst, Salt Lake City, UT 84108 USA Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Psychiat & Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 iat & Genet, St Louis, MO 63110 USA Univ Minnesota, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 1, volume: 17, anno: 1999,
pagine: 39 - 43
SICI:
0263-6352(199901)17:1<39:NLOTLL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL COMBINED HYPERLIPIDEMIA; EXTENDED PEDIGREE; LPL GENE; DEFICIENCY; UTAH; INDIVIDUALS; PROBAND;
Keywords:
blood pressure; genetics; lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hunt, SC UnivCity,, Sch Med, Dept Internal Med, 410 Chipeta Way,Room 167, Salt Lake Univ Utah 410 Chipeta Way,Room 167 Salt Lake City UT USA 84108 ke
Citazione:
S.C. Hunt et al., "No linkage of the lipoprotein lipase locus to hypertension in Caucasians", J HYPERTENS, 17(1), 1999, pp. 39-43

Abstract

Objective A previous study has shown significant linkage of five markers near the lipoprotein lipase locus to systolic blood pressure, but not to diastolic blood pressure, in nondiabetic members of 48 Taiwanese families selected for noninsulin-dependent diabetes. However, lipoprotein lipase markersdid not appear strongly linked to systolic blood pressure in a study of Mexican-Americans using a variety of selection schemes. The objective of the current study was to test whether markers near the lipoprotein lipase gene were linked to hypertension in Caucasians. Design To test for linkage of genetic markers in or near the lipoprotein lipase gene to hypertension in Caucasians, two sets of Caucasian hypertensive sibships were genotyped. The samples included 261 sibships (431 effectivesibpairs) from four field centers of the National Heart, Lung and Blood Institute Family Heart Study and 211 sibships (282 effective sibpairs) from the Health Family Tree database in Utah. Results Two highly polymorphic markers in or near the lipoprotein lipase gene showed no evidence of excess allele sharing in either set of hypertensive sibships. Combining the two datasets resulted in 653 and 713 effective sibpairs for the two markers, sharing 0.495 +/- 0.30 and 0.486 +/- 0.28 alleles identical by descent compared to an expected sharing of 0.50. Multipoint analysis of the two loci also did not show linkage (P = 0.95). Conclusions We conclude that the lipoprotein lipase locus and nearby regions do not appear to be linked to hypertension in Caucasians. J Hypertens 1999, 17:39-43 (C) Lippincott Williams & Wilkins.

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Documento generato il 02/04/20 alle ore 01:42:50