Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Baroreflex sensitivity changes with calcium antagonist therapy in elderly subjects with isolated systolic hypertension
Autore:
James, MA; Rakicka, H; Panerai, RB; Potter, JF;
Indirizzi:
Univics,cester, Glenfield Gen Hosp, Dept Med Elderly, Leicester LE3 9QP, Le Univ Leicester Leicester Leics England LE3 9QP rly, Leicester LE3 9QP, Le
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 2, volume: 13, anno: 1999,
pagine: 87 - 95
SICI:
0950-9240(199902)13:2<87:BSCWCA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINE ANTIHYPERTENSIVE AGENTS; ARTERIAL BLOOD-PRESSURE; REFLEX CARDIAC CONTROL; HEART-RATE REFLEX; CARDIOVASCULAR REFLEXES; VALSALVA MANEUVER; VARIABILITY; NIFEDIPINE; APPROPRIATE; MODULATION;
Keywords:
elderly; baroreflex; nifedipine; phenylephrine; nitroprusside; Valsalva's manoeuvre;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: James, MA Royal Devon & Exeter Hosp, Barrack Rd, Exeter EX2 5DW, Devon, England Royal Devon & Exeter Hosp Barrack Rd Exeter Devon England EX2 5DW
Citazione:
M.A. James et al., "Baroreflex sensitivity changes with calcium antagonist therapy in elderly subjects with isolated systolic hypertension", J HUM HYPER, 13(2), 1999, pp. 87-95

Abstract

In order to study the effects of calcium-blocking therapy on cardiovascular homeostasis in elderly subjects with isolated systolic hypertension, we performed a randomised double-blind placebo-controlled crossover study of 6 weeks therapy with modified-release nifedipine or placebo. Changes with calcium-blocker treatment in clinic and 24-h blood pressure (BP), heart rate, BP variability, baroreflex sensitivity (BRS) by three methods (Valsalva manoeuvre, phenylephrine and sodium nitroprusside injection), and in baroreflex- and non-baroreflex-mediated reflexes (tilt and cold face stimulus) were studied in 14 elderly subjects (mean age [+/- SEM] 70 +/- 1 years) with sustained isolated systolic hypertension (clinic BP 179 +/- 3/85 +/- 1 mm Hg). Clinic systolic BP, but not diastolic BP, was reduced with treatment (by 14 +/- 6 mm Hg, P = 0.03, diastolic BP 4 +/- 3 mm Hg, P = 0.16). Twenty-fourhour BP was also reduced by nifedipine treatment (by 18 +/- 3/9 +/- 2 mm Hg, both P < 0.001). Clinic and 24-h heart rate, and daytime BP variability,were unchanged with treatment. BRS was significantly increased during nifedipine therapy by all three measurement methods (all P < 0.05). With 60 degrees tilt during active treatment, subjects exhibited a greater heart rate increase (P < 0.01), and a reduced tall in systolic (P < 0.05) and diastolic BP (P < 0.05). Thus despite the arteriosclerosis and reductions in large artery compliance described in elderly patients with isolated systolic hypertension, clinically important improvements in clinic and ambulatory BP andsome aspects of cardiovascular homeostasis can be achieved with calcium-channel blocking therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:14:00