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Titolo:
Determinants of peak bone mass: Clinical and genetic analyses in a young female Canadian cohort
Autore:
Rubin, LA; Hawker, GA; Peltekova, VD; Fielding, LJ; Ridout, R; Cole, DEC;
Indirizzi:
Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Rheumatol, Toronto, ON M5S 1B6, Sunnybrook & Womens Coll Toronto ON Canada M5S 1B6 , Toronto, ON M5S 1B6, Sunnybrookram,omens Coll, Hlth Sci Ctr, Multidisciplinary Osteoporosis Prog Sunnybrook & Womens Coll Toronto ON Canada M5S 1B6 nary Osteoporosis Prog Univ Toronto, Dept Med, Toronto, ON, Canada Univ Toronto Toronto ON Canada iv Toronto, Dept Med, Toronto, ON, Canada Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Endocrinol, Toronto, ON, Canada Sunnybrook & Womens Coll Toronto ON Canada docrinol, Toronto, ON, Canada Toronto Hosp, Dept Med, Toronto, ON M5T 2S8, Canada Toronto Hosp Toronto ON Canada M5T 2S8 t Med, Toronto, ON M5T 2S8, Canada Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto, Dept Paediat Genet, Toronto, ON, Canada Univ Toronto Toronto ON Canada , Dept Paediat Genet, Toronto, ON, Canada
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 4, volume: 14, anno: 1999,
pagine: 633 - 643
SICI:
0884-0431(199904)14:4<633:DOPBMC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D-RECEPTOR; MINERAL DENSITY; CALCIUM-ABSORPTION; SERUM 1,25-DIHYDROXYVITAMIN-D; POSTMENOPAUSAL WOMEN; PREMENOPAUSAL WOMEN; OSTEOPOROSIS; ALLELES; POLYMORPHISMS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, LA Sunnybrook0& Womens Coll, Hlth Sci Ctr, Div Rheumatol, Womens Coll Campus,6 Sunnybrook & Womens Coll Womens Coll Campus,60 Grosvenor St,Suite 416 Toronto ON Canada M5S 1B6
Citazione:
L.A. Rubin et al., "Determinants of peak bone mass: Clinical and genetic analyses in a young female Canadian cohort", J BONE MIN, 14(4), 1999, pp. 633-643

Abstract

Peak bone mass has been shown to be a significant predictor of risk for osteoporosis. Previous studies have demonstrated that skeletal mass accumulation is under strong genetic control, and efforts have been made to identifycandidate loci. Determinants of peak bone mass also include diet, physicalactivity, hormonal status, and other clinical factors. The overall contribution of these factors, genetic and nongenetic, and their interaction in determining peak bone density status have not been delineated. Six hundred and seventy-seven healthy unrelated Caucasian women ages 18-35 years were assessed. A detailed, standardized interview was conducted to evaluate lifestyle factors, menstrual and reproductive history, medical conditions, medication use, and family history of osteoporosis. Bone mineral density (BMD) wasmeasured at the lumbar spine (L2-L4) and the femoral neck (hip) using dual-energy X-ray absorptiometry. Genotyping of the vitamin D receptor (VDR) locus at three polymorphic sites (BsmI, ApaI, and TaqI) was performed. In bivariate analyses, BMD at the lumbar spine and hip was positively correlated with weight, height, body mass index (BMI), and level of physical activity,both now and during adolescence, but negatively correlated with a family history of osteoporosis. Hip, but not spine BMD, correlated positively with dietary intake of calcium, and negatively with amenorrhea of more than 3 months, with caffeine intake, and with age. Spine, but not hip BMD, correlated positively with age and with number of pregnancies. VDR haplotype demonstrated significant associations with BMD at the hip, level of physical activity currently, and BMI. In multivariate analysis, independent predictors ofgreater BMD (at the hip or spine) were: age (younger for the hip, older for the spine), greater body, weight, greater height (hip only), higher levelof physical activity now and during adolescence, no family history of osteoporosis, and VDR genotype (hip only). Weight, age, level of physical activity, and family history are independent predictors of peak BMD. Of these factors, weight accounts for over half the explained variability in BMD. VDR alleles are significant independent predictors of peak femoral neck, but not lumbar spine BR;ID, even after adjusting for family history of osteoporosis, weight, age, and exercise. However, the overall contribution of this genetic determinant is modest. Taken together, these factors explained similar to 17% and 21% of the variability in peak spine and hip BMD, respectively, in our cohort. Future research should be aimed at further evaluation of genetic determinants of BR ID. Most importantly, understanding the critical interactive nature between genes and the environment will facilitate development of targeted strategies directed at modifying lifestyle factors as webas earlier intervention in the most susceptible individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:49:54