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Titolo:
THE VALUE OF QUANTITATIVE MYOCARDIAL PERFUSION IMAGING WITH POSITRON EMISSION TOMOGRAPHY IN CORONARY-ARTERY DISEASE
Autore:
WIJNS W; CAMICI PG;
Indirizzi:
ONZE LIEVE VROUW HOSP,CTR CARDIOVASC,164 MOORSELBAAN B-9300 AALST BELGIUM CTR CARDIOVASC AALST BELGIUM MRC,CTR CLIN SCI,CYCLOTRON UNIT LONDON ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH LONDON ENGLAND
Titolo Testata:
Herz
fascicolo: 2, volume: 22, anno: 1997,
pagine: 87 - 95
SICI:
0340-9937(1997)22:2<87:TVOQMP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLATERAL-DEPENDENT MYOCARDIUM; REGIONAL BLOOD-FLOW; N-13 AMMONIA; VASODILATOR RESERVE; HYPERTROPHIC CARDIOMYOPATHY; NONINVASIVE QUANTIFICATION; COMPUTED-TOMOGRAPHY; HIGH-RISK; METABOLISM; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
W. Wijns e P.G. Camici, "THE VALUE OF QUANTITATIVE MYOCARDIAL PERFUSION IMAGING WITH POSITRON EMISSION TOMOGRAPHY IN CORONARY-ARTERY DISEASE", Herz, 22(2), 1997, pp. 87-95

Abstract

Positron Emission Tomography (PET) is the only available technique that permits quantification of regional myocardial perfusion in humans. To this end, tracer kinetic models and appropriate tracers such as N-13-Ammonia and O-15 labeled water are required. Quantification is possible because accurate radioactivity quantities can be measured externally, both for the vascular and myocardial compartments. Normal value for baseline and maximal perfusion after pharmacologically induced vasodilatation of the resistance microcirculatory vessels are age-dependent. The functional hemodynamic significance of epicardial stenoses can be estimated from the progressive reduction in coronary perfusion reserve, which decreases progressively when stenosis severity reaches 40% in diameter. The effect of revascularization procedures such as CABG and PTCA can be objectively measured. In addition, there is increasing evidence from PET studies that resistive vessel dysfunction (probably through endothelial factors) contributes to the reduced perfusion reserve in patients with epicardial coronary artery disease. Therefore, quantification of myocardial perfusion with PET appears an ideally suitedendpoint for primary and secondary prevention trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:32:22