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Titolo:
Influence of ruminal bypass on the pharmacokinetics and efficacy of benzimidazole anthelmintics in sheep
Autore:
Steel, JW; Hennessy, DR;
Indirizzi:
CSIRO, Mcmaster Lab, Blacktown, NSW 2148, Australia CSIRO Blacktown NSW Australia 2148 er Lab, Blacktown, NSW 2148, Australia
Titolo Testata:
INTERNATIONAL JOURNAL FOR PARASITOLOGY
fascicolo: 2, volume: 29, anno: 1999,
pagine: 305 - 314
SICI:
0020-7519(199902)29:2<305:IORBOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICHOSTRONGYLUS-COLUBRIFORMIS; HAEMONCHUS-CONTORTUS; OXFENDAZOLE; FENBENDAZOLE; ALBENDAZOLE; METABOLITES; DISPOSITION; RESISTANCE; BEHAVIOR; TUBULIN;
Keywords:
oxfendazole; fenbendazole; albendazole; pharmacokinetics; rumen bypass; absorption; efficacy; benzimidazole resistance; sheep;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Steel, JW CSIRO,liamaster Lab, Locked Bag 1,Delivery Ctr, Blacktown, NSW 2148, Austra CSIRO Locked Bag 1,Delivery Ctr Blacktown NSW Australia 2148 tra
Citazione:
J.W. Steel e D.R. Hennessy, "Influence of ruminal bypass on the pharmacokinetics and efficacy of benzimidazole anthelmintics in sheep", INT J PARAS, 29(2), 1999, pp. 305-314

Abstract

Oxfendazole, fenbendazole and albendazole were each administered at 5 mg kg(-1) to sheep fitted with abomasal cannulae as a single bolus intra-ruminally or infused intra-abomasally at a declining exponential rate, with half-life equivalent to the rate of rumen fluid outflow. The pharmacokinetic disposition of parent compound and metabolites in plasma and abomasal fluid was determined by high performance liquid chromatography. Compared with intra-ruminal administration, intra-abomasal infusion of fenbendazole lowered the area under the concentration-time curve of drug in both plasma and abomasal fluid; intra-abomasal infusion of albendazole substantially increased maximum drug concentration and the concentration-time curve in abomasal fluidand lowered the plasma concentration-time curve of the sulphoxide metabolite; intra-abomasal infusion of oxfendazole increased maximum concentration and the concentration-time curve of drug in plasma and abomasal fluid. The greater availability in abomasal fluid of oxfendazole and albendazole when given at commercial dose rates of 5 mg kg(-1) and 3.9 mg kg(-1), respectively, by intra-abomasal infusion correlated with increased efficacy of both drugs against benzimidazole-resistant Trichostrongylus colubriformis and of albendazole against benzimidazole-resistant Haemonchus contortus over that achieved by intra-ruminal administration as a single bolus. (C) 1999 Australian Society for Parasitology. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:47:57