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Titolo:
HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates
Autore:
Heeney, J; Akerblom, L; Barnett, S; Bogers, W; Davis, D; Fuller, D; Koopman, G; Lehner, T; Mooij, P; Morein, B; Morghen, CD; Rosenwirth, B; Verschoor, E; Wagner, R; Wolf, H;
Indirizzi:
Biomed Primate Res Ctr, Dept Virol, NL-2288 GH Rijswijk, Netherlands Biomed Primate Res Ctr Rijswijk Netherlands NL-2288 GH wijk, Netherlands Swedish Univ Agr Sci, S-75123 Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden S-75123 Sci, S-75123 Uppsala, Sweden Natl Vet Inst, Dept Virol, Ctr Biomed, S-75123 Uppsala, Sweden Natl Vet Inst Uppsala Sweden S-75123 Ctr Biomed, S-75123 Uppsala, Sweden Chiron Corp, Emeryville, CA 94608 USA Chiron Corp Emeryville CA USA 94608Chiron Corp, Emeryville, CA 94608 USA Inst Trop Med, Dept Microbiol, Virol Unit, B-2000 Antwerp, Belgium Inst Trop Med Antwerp Belgium B-2000 Virol Unit, B-2000 Antwerp, Belgium Powderject Vaccines, Madison, WI 53711 USA Powderject Vaccines Madison WIUSA 53711 Vaccines, Madison, WI 53711 USA UnitednMed & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Dept Immunol, Londo United Med & Dent Sch Guys & St Thomas Hosp London England SE1 9RT Londo Univ Milan, Dept Pharmacol, Mol Virol Lab, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 acol, Mol Virol Lab, I-20129 Milan, Italy Univ Regensburg, Inst Med Mikrobiol & Hyg, D-95053 Regensburg, Germany Univ Regensburg Regensburg Germany D-95053 , D-95053 Regensburg, Germany
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 1-3, volume: 66, anno: 1999,
pagine: 189 - 195
SICI:
0165-2478(199903)66:1-3<189:HVIRWC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELLS; ENVELOPE; CHIMPANZEES; MACAQUES; MONKEYS; MIP-1-ALPHA; MIP-1-BETA; EXPRESSION; RECEPTOR;
Keywords:
HIV-1; vaccine; immunity; pre-clinical; immune responses; correlation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Heeney, J Biomedndsimate Res Ctr, Dept Virol, POB 3306, NL-2288 GH Rijswijk, Netherla Biomed Primate Res Ctr POB 3306 Rijswijk Netherlands NL-2288 GH
Citazione:
J. Heeney et al., "HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates", IMMUNOL LET, 66(1-3), 1999, pp. 189-195

Abstract

The specific immune mechanisms necessary and/or sufficient to elicit HIV-vaccine protection remain undefined. Utilising the SHIV rhesus macaque modelthe immunogenicity as well as the efficacy of ten different HIV-1 vaccine candidates was evaluated. Comparison of the immune responses induced, with the ability of the vaccine to protect from SHIV infection provided a means to determine which type of immune responses were necessary for protection. Vaccine candidates included VLPs, DNA, subunit protein with novel adjuvant formulations, ISCOMs and pox-virus vectors. Protection from SHIV infection was achieved in approximately half of the animals which received a primary intravenous cell-free challenge. The presence of CTL in the absence of other effector responses did not correlate with protection from this route and type of challenge. Virus neutralising antibodies (Nab) appeared to be necessary but alone were insufficient for protection. If Ag-specific IFN-gamma and/or IL-4 as well as lymphoproliferative (LP) responses were found with the lack of a detectable IL-2 response, then protection was not observed. Immunity correlated with the magnitude of Nab responses, beta-chemokines and as well as balanced, qualitative T-helper responses. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/12/20 alle ore 22:35:10