Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A mathematical model of the carotid baroregulation in pulsating conditions
Autore:
Ursino, M;
Indirizzi:
Dept Elect Comp Sci & Syst, I-140136 Bologna, Italy Dept Elect Comp Sci & Syst Bologna Italy I-140136 -140136 Bologna, Italy
Titolo Testata:
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
fascicolo: 4, volume: 46, anno: 1999,
pagine: 382 - 392
SICI:
0018-9294(199904)46:4<382:AMMOTC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINUS BARORECEPTOR REFLEX; INPUT IMPEDANCE; ANESTHETIZED DOGS; PRESSURE; BAROREFLEX; VOLUME; SYSTEM; HEART; CAPACITANCE; CIRCULATION;
Keywords:
arterial pressure regulation; baroreflex; carotid baroreceptors; pressure pulsatility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ursino, M Dept Elect Comp Sci & Syst, Viale Risorgimento 2, I-140136 Bologna, Italy Dept Elect Comp Sci & Syst Viale Risorgimento 2 Bologna Italy I-140136
Citazione:
M. Ursino, "A mathematical model of the carotid baroregulation in pulsating conditions", IEEE BIOMED, 46(4), 1999, pp. 382-392

Abstract

A mathematical model of short-term arterial pressure control by the carotid baroreceptors in vagotomized subjects is presented, It includes an elastance variable description of the left and right heart, the systemic and pulmonary circulations, the afferent carotid baroreceptor pathway, a central elaboration unit, and the action of five effector mechanisms. Simulation results suggest that the carotid baroreflex is able to significantly modulate the cardiac function curve, but this effect is masked in vivo by changes in arterial pressure and atrial pressure. During heart pacing,cardiac output increases with frequency at moderate levels of heart rate, then fails to increase further due to a reduction in stroke volume. Shifting from nonpulsatile to pulsatile perfusion of the carotid sinuses decreasesthe overall baroreflex gain. Finally, a sensitivity analysis suggests thatvenous unstressed volume control plays the major role in the early hemodynamic response to acute hemorrhage, whereas systemic resistance control is less important. In all cases, there has been satisfactory agreement between model and experimental results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 22:35:54