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Titolo:
Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray
Autore:
Wang, K; Gan, L; Jeffery, E; Gayle, M; Gown, AM; Skelly, M; Nelson, PS; Ng, WV; Schummer, M; Hood, L; Mulligan, J;
Indirizzi:
Chirosci R&D Inc, Bothell, WA 98021 USA Chirosci R&D Inc Bothell WA USA 98021 osci R&D Inc, Bothell, WA 98021 USA Univ Washington, Dept Pathol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pathol, Seattle, WA 98195 USA Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ol Biotechnol, Seattle, WA 98195 USA
Titolo Testata:
GENE
fascicolo: 1-2, volume: 229, anno: 1999,
pagine: 101 - 108
SICI:
0378-1119(19990318)229:1-2<101:MGEPCI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY EPITHELIAL-CELLS; MOLECULAR-CLONING; PROTEIN; POLYMERASE; DNA;
Keywords:
array; carcinogenesis; ovarian cancer; RT-PCR; tumor marker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, K Chirosci R&D Inc, 1631 220th SE, Bothell, WA 98021 USA Chirosci R&D Inc 1631 220th SE Bothell WA USA 98021 , WA 98021 USA
Citazione:
K. Wang et al., "Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray", GENE, 229(1-2), 1999, pp. 101-108

Abstract

The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:07:34