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Titolo:
Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt
Autore:
Westrin, A; Ekman, R; Traskman-Bendz, L;
Indirizzi:
Univ Lund, Div Psychiat, Dept Clin Neurosci, Lund, Sweden Univ Lund LundSweden d, Div Psychiat, Dept Clin Neurosci, Lund, Sweden Univ Gothenburg, Dept Psychiat & Neurochem, Inst Clin Neurosci, Gothenburg, Univ Gothenburg Gothenburg Sweden chem, Inst Clin Neurosci, Gothenburg,
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 9, anno: 1999,
pagine: 205 - 211
SICI:
0924-977X(199903)9:3<205:AOCRH(>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; KILLER-CELL ACTIVITY; BETA-ENDORPHIN; DEPRESSED-PATIENTS; MAJOR DEPRESSION; CEREBROSPINAL-FLUID; CORTISOL; STRESS; BEHAVIOR;
Keywords:
suicide attempt; major depression; corticotropin-releasing hormone; neuropeptide Y; beta-endorphins; HPA axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Westrin, A Univ Lund, Div Psychiat, Dept Clin Neurosci, Lund, Sweden Univ Lund Lund Sweden hiat, Dept Clin Neurosci, Lund, Sweden
Citazione:
A. Westrin et al., "Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt", EUR NEUROPS, 9(3), 1999, pp. 205-211

Abstract

In order to receive a further understanding of stress-regulation in depressed suicide attempters, peptides that are supposed to be related to the stress system (the hypothalamic-pituitary-adrenal (HPA) axis and the autonomicnervous system) were studied in plas ma. When compared with healthy controls, cortisol was high (p<0.001) and corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) appeared to be low (p<0.001) in patients who had recently attempted suicide. Patients who had repeatedly attempted suicide hadthe lowest NPY. A correlation between NPY and cortisol (p<0.05) was found in suicidal patients with depression NOS, whereas beta-endorphins correlated with cortisol (p<0.01) in suicidal patients with major depressive disorder. A postdexamethasone decrease of NPY was noted in the controls but not inthe patients. These results suggest stress system alterations in suicidal patients with mood disorders. (C) 1999 Elsevier Science B.V./ECNP All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:57:10