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Titolo:
Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice
Autore:
Borowicz, KK; Kaminski, R; Gasior, M; Kleinrok, Z; Czuczwar, SJ;
Indirizzi:
Lublin Med Univ Sch, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland Lublin Med Univ Sch Lublin Poland PL-20090 icol, PL-20090 Lublin, Poland Inst Rural Med, Dept Clin Toxicol, PL-20090 Lublin, Poland Inst Rural MedLublin Poland PL-20090 n Toxicol, PL-20090 Lublin, Poland
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 9, anno: 1999,
pagine: 185 - 190
SICI:
0924-977X(199903)9:3<185:IOMUTP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PINEAL-GLAND; ANTICONVULSANT ACTION; ANTIEPILEPTIC DRUGS; CONVULSIONS; SEIZURES; CHILDREN; GERBILS; FEBRILE; RATS;
Keywords:
melatonin; anti-epileptic drugs; maximal electroshock; long-term memory; seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Czuczwar, SJ Lublinlin, Univ Sch, Dept Pharmacol & Toxicol, Jaczewskiego 8, PL-20090 Lub Lublin Med Univ Sch Jaczewskiego 8 Lublin Poland PL-20090 ub
Citazione:
K.K. Borowicz et al., "Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice", EUR NEUROPS, 9(3), 1999, pp. 185-190

Abstract

Melatonin (50 mg/kg; 60 min before the test) significantly raised the electroconvulsive threshold in mice. The protective action of melatonin (50 mg/kg) in the electroconvulsive threshold test was reversed by aminophylline, picrotoxin and bicuculline. Melatonin at the subconvulsive dose of 25 mg/kgpotentiated the anticonvulsive activity of carbamazepine and phenobarbital(ED50 values were significantly decreased from 12.1 to 8.3 and from 18.9 to 11.8 mg/kg, respectively). No potentiation was observed in the case of valproate and diphenylhydantoin (their ED(50)s were changed from 253 to 249 and from 10.3 to 9.7 mg/kg, respectively). Melatonin did not influence the plasma or brain levels of anti-epileptics studied, so a pharmacokinetic interaction is not probable. Melatonin (25 mg/kg) alone and its combinations with carbamazepine or phenobarbital, providing a 50% protection against maximal electroshock, were devoid of significant motor adverse effects, but caused strong long-term memory deficit. Consequently, it does not seem to be a good candidate for the treatment of epilepsy. (C) 1999 Elsevier Science B.V./ECNP All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:30:56