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Titolo:
Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats
Autore:
Vergoni, AV; Bertolini, A; Wikberg, JES; Schioth, HB;
Indirizzi:
UppsalanUniv, Ctr Biomed, Dept Pharmaceut Pharmacol, S-75124 Uppsala, Swede Uppsala Univ Uppsala Sweden S-75124 ut Pharmacol, S-75124 Uppsala, Swede Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 369, anno: 1999,
pagine: 11 - 15
SICI:
0014-2999(19990312)369:1<11:SMMRBR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANALOGS;
Keywords:
melanocortin receptor; MSH (melanocyte-stimulating hormone); HS014; food intake; immobilization stress; anorexia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Schioth, HB Uppsalala,iv, Ctr Biomed, Dept Pharmaceut Pharmacol, Box 591, S-75124 Uppsa Uppsala Univ Box 591 Uppsala Sweden S-75124 91, S-75124 Uppsa
Citazione:
A.V. Vergoni et al., "Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats", EUR J PHARM, 369(1), 1999, pp. 11-15

Abstract

We investigated the effects of selective melanocortin MC4 receptor blockage on immobilization stress-induced anorexia. Male rats were subjected to immobilization once a day for 4 days. Prior to each of the stress treatments,the rats were injected i.c.v. (intracerebroventricularly) with either saline or the melanocortin MC4 receptor antagonist HS014 (cyclic [AcCys(11), D-Nal(14), Cys(18) Asp-NH222]beta-MSH-(11-22) (melanocyte-stimulating hormone). Rats subjected to neither stress nor i.c.v. injections served as controls. The results showed that the cumulative food intake and body weight gain in the stressed group treated with HS014 was significantly higher than in the stressed group and significantly lower than in the control group. Repeated injections of the melanocoain MC4 receptor antagonist were effective andthere were no signs of tachyphylaxis. This is the first report showing that melanocortin MC4 receptor blockage can relieve an anorectic condition, which may indicate that melanocortin MC4 receptor blockage is an effective way to treat anorectic disorders. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:36:46