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Titolo:
Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains
Autore:
Suzuki, T; Ise, Y; Maeda, J; Misawa, M;
Indirizzi:
Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 xicol, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ, Sch Pharm, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 macol, Shinagawa Ku, Tokyo 1428501, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 369, anno: 1999,
pagine: 159 - 162
SICI:
0014-2999(19990319)369:2<159:MNAILA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; PHYSICAL-DEPENDENCE; LOCOMOTOR-ACTIVITY; ETHANOL; SYSTEM;
Keywords:
conditioned place preference paradigm; mecamylamine; withdrawal aversion; physical dependence; nicotine; Lewis rat; Fischer 344 rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Hoshi501,v, Sch Pharm, Dept Toxicol, Shinagawa Ku, 2-4-41 Ebara,Tokyo 1428 Hoshi Univ 2-4-41 Ebara Tokyo Japan 1428501 1 Ebara, Tokyo 1428
Citazione:
T. Suzuki et al., "Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains", EUR J PHARM, 369(2), 1999, pp. 159-162

Abstract

Many studies have indicated that Lewis and Fischer 344 inbred rat strains show marked differences in behavioral responses to abused drugs. In the present study, we sought to determine whether these two strains of rats show different responses in mecamylamine-precipitated nicotine-withdrawal aversion using the conditioned place preference paradigm. Rats were treated subcutaneously with 10 mg/kg/day nicotine for 7 days using an osmotic minipump. After chronic nicotine infusion, the nicotinic receptor antagonist mecamylamine produced a significant place aversion in Lewis, but not in Fischer 344 rats. These results suggest that mecamylamine-precipitated nicotine-withdrawal aversion is strongly regulated by genetic factors. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 13/07/20 alle ore 07:57:43