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Titolo:
The polymerization ratchet model explains the force-velocity relation for growing microtubules
Autore:
Mogilner, A; Oster, G;
Indirizzi:
Univ Calif Davis, Dept Math, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Davis, Dept Math, Davis, CA 95616 USA Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA UnivCalif Berkeley Berkeley CA USA 94720 ar Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Coll Nat Resources, Berkeley, CA 94720 USA Univ CalifBerkeley Berkeley CA USA 94720 sources, Berkeley, CA 94720 USA
Titolo Testata:
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
fascicolo: 3, volume: 28, anno: 1999,
pagine: 235 - 242
SICI:
0175-7571(1999)28:3<235:TPRMET>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINESIN; ACTIN;
Keywords:
filamentous proteins; polymerization rachet model; microtubules; force-velocity relationship;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Mogilner, A Univ Calif Davis, Dept Math, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Math, Davis, CA 95616 USA
Citazione:
A. Mogilner e G. Oster, "The polymerization ratchet model explains the force-velocity relation for growing microtubules", EUR BIOPHYS, 28(3), 1999, pp. 235-242

Abstract

The polymerization of filamentous proteins generates mechanical forces which drive many cellular processes. Dogterom and Yurke measured the force-velocity relation generated by a single microtubule. They found that the forceis generally in the range predicted by the "polymerization ratchet" mechanism, but the force-velocity relationship decreased faster than that theory predicted. Here we generalize the polymerization ratchet model to take intoaccount the "subsidy effect" that arises because a microtubule consists of13 protofilaments. With this generalization the model fits the experimental data well. The biological implications of the polymerization ratchet model are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:19:41