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Titolo:
Environmental risk assessment for the widely used iodinated X-ray contrastagent iopromide (Ultravist)
Autore:
Steger-Hartmann, T; Lange, R; Schweinfurth, H;
Indirizzi:
Schering AG, Res Labs, D-1000 Berlin, Germany Schering AG Berlin GermanyD-1000 g AG, Res Labs, D-1000 Berlin, Germany
Titolo Testata:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
fascicolo: 3, volume: 42, anno: 1999,
pagine: 274 - 281
SICI:
0147-6513(199903)42:3<274:ERAFTW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Steger-Hartmann, T Schering AG, Res Labs, Mullerstr 170-178, D-1000 Berlin, Germany Schering AG Mullerstr 170-178 Berlin Germany D-1000 ny
Citazione:
T. Steger-Hartmann et al., "Environmental risk assessment for the widely used iodinated X-ray contrastagent iopromide (Ultravist)", ECOTOX ENV, 42(3), 1999, pp. 274-281

Abstract

Iodinated S-ray contrast media are diagnostic pharmaceuticals that are applied to enhance the contrast between organs or vessels examined and surrounding tissues during radiography. These substances are applied in doses up to ca, 200 g per person (corresponding to approx 100 g iodine) and are rapidly excreted. In the sewage system they contribute to the burden of adsorbable organic halogens (AOX). To assess the potential environmental impact of this release, studies on environmental fate and effects mere conducted for a risk assessment of the frequently used X-rag contrast medium iopromide (brand name: Ultravist). A screening test for biological degradation (OECD Screening Test 301 E) led to iopromide being classified as not readily biodegradable, Therefore, the predicted environmental concentration (PEC) in surface mater was calculated in a first step. The resulting concentration of 2 mu g/liter was then compared in a second step with the predicted no-effect concentration as derived from a battery of ecotoxicity tests. In short-termtoxicity tests with bacterial (Vibrio fisheri, Pseudomonas putida), algae (Scenedesmus subspicatus), crustaceans (Daphnia magna), and fish (Danio rerio, Leuciscus idus) no toxic effects were detected at the highest tested concentration of 10 g/liter, In a chronic toxicity test with D, magna no effect was observed at the highest tested concentration of 1 g/liter. Using an assessment factor of 100 the ratio between the predicted environmental concentration (PEC) and the predicted no-effect concentration (PNEC) was calculated to be less than or equal to 0.0002. This low value indicates that no environmental risk has to be expected as a result of the release of iopromide into the aquatic environment, (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 15:00:42