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Titolo:
Managing antipsychotic-induced parkinsonism
Autore:
Mamo, DC; Sweet, RA; Keshavan, MS;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA
Titolo Testata:
DRUG SAFETY
fascicolo: 3, volume: 20, anno: 1999,
pagine: 269 - 275
SICI:
0114-5916(199903)20:3<269:MAP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED PARKINSONISM; DRUG-INDUCED PARKINSONISM; DOUBLE-BLIND; ELDERLY PATIENTS; EXTRAPYRAMIDAL SYMPTOMS; SCHIZOPHRENIA; HALOPERIDOL; AMANTADINE; RISPERIDONE; DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Mamo, DC Western15213hiat Inst & Clin, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA Western Psychiat Inst & Clin 3811 Ohara St Pittsburgh PA USA 15213
Citazione:
D.C. Mamo et al., "Managing antipsychotic-induced parkinsonism", DRUG SAFETY, 20(3), 1999, pp. 269-275

Abstract

Notwithstanding the advent of clozapine and other 'atypical' antipsychoticagents, the conventional ('typical') antipsychotic agents remain in widespread use. Antipsychotic-induced parkinsonism is a highly prevalent adverse effect that may result in increased morbidity and noncompliance. Bedside examination is generally sufficient for the detection of the onsetof parkinsonism and should be carried out frequently in the first 3 monthsof treatment. In addition to decreasing patient discomfort, monitoring forantipsychotic-induced parkinsonism also serves to identify the minimally effective dosage required for the individual patient. Several strategies are utilised in the management of antipsychotic-inducedparkinsonism including dosage reduction, switching to other antipsychotic agents and the use of antiparkinsonian drugs such as anticholinergic agentsand amantadine,Anticholinergic agents remain the mainstay of the pharmacological management of antipsychotic-induced parkinsonism in younger patients. Amantadine isa better tolerated agent for elderly patients, with similar efficacy to the anticholinergic agents. The routine use of prophylactic anticholinergics is not recommended and is clearly contraindicated in the elderly. An individualised risk-benefit assessment is necessary for the younger patient in whom prophylactic use of anticholinergic drugs is considered.

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Documento generato il 27/01/20 alle ore 07:58:14