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Titolo:
Substitution therapy in patients with major depression
Autore:
Joffe, RT;
Indirizzi:
McMaster Univ, Reg Mood Disorders Program, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 am, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
CNS DRUGS
fascicolo: 3, volume: 11, anno: 1999,
pagine: 175 - 180
SICI:
1172-7047(199903)11:3<175:STIPWM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSPECTIVE FOLLOW-UP; REFRACTORY DEPRESSION; RECURRENT DEPRESSION; ATYPICAL DEPRESSION; PANIC ATTACKS; DISORDER; FLUOXETINE; ANTIDEPRESSANT; RESISTANT; INTOLERANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Joffe, RT McMastern,niv, Reg Mood Disorders Program, 1200 Main St W,Room 2E1, Hamilto McMaster Univ 1200 Main St W,Room 2E1 Hamilton ON Canada L8N 3Z5
Citazione:
R.T. Joffe, "Substitution therapy in patients with major depression", CNS DRUGS, 11(3), 1999, pp. 175-180

Abstract

Antidepressants are one of the most effective treatments for major depressive disorder. However, despite optimal treatment, a substantial number of patients, up to 50%, may have a partial or no response to the first antidepressant used. In such cases, several options are available. These include substitution of the first antidepressant with a second antidepressant, often of a different class, or various combination or augmentation strategies. In general, substitution is a well tolerated and effective way of managingtreatment-resistant depression. Switching to an alternative class of antidepressants usually increases the chances of treatment response, although with the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) a second trial may be attempted with the same class of drug. In general, a washout period between trials of different compounds is not necessary, except when first generation monoamine oxidase inhibitors are used. In that situation, an appropriate washout period is required when switching toor from this class of compound, particularly when switching to or from theSSRIs. Further studies are required to determine the relative benefits of augmentation/combination versus substitution treatment of refractory depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:44:16