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Titolo:
Sensory gating of the P13 midlatency auditory evoked potential and the startle response in the rat
Autore:
Miyazato, H; Skinner, RD; Garcia-Rill, E;
Indirizzi:
Univ Arkansas Med Sci, Dept Anat, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 822, anno: 1999,
pagine: 60 - 71
SICI:
0006-8993(19990320)822:1-2<60:SGOTPM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDUNCULOPONTINE TEGMENTAL NUCLEUS; ACOUSTIC STARTLE; SCHIZOPHRENIC-PATIENTS; NEUROPHYSIOLOGICAL EVIDENCE; DECREASED HABITUATION; CHOLINERGIC NEURONS; PREPULSE INHIBITION; ANIMAL-MODEL; NORMALIZATION; REFLEX;
Keywords:
auditory evoked potential; P1 potential; startle; prepulse inhibition; sensory gating; pedunculopontine nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Rill, E UnivUSAkansas Med Sci, Dept Anat, 4301 W Markham St, LittleRock, AR 72205 Univ Arkansas Med Sci 4301 W Markham St Little Rock AR USA 72205
Citazione:
H. Miyazato et al., "Sensory gating of the P13 midlatency auditory evoked potential and the startle response in the rat", BRAIN RES, 822(1-2), 1999, pp. 60-71

Abstract

The human P1/P50 midlatency auditory evoked potential and the startle response (SR) have been used as measures of sensory and sensorimotor gating, respectively. In the present study, both prepulse and paired stimulus paradigms were used in order to investigate the relationship between sensory gating mechanisms of the P13 potential, the putative rodent equivalent of the pipotential, and those of the SR. Tn addition, these were compared to the properties of the N40 potential, another measure of sensory gating. Simultaneous recordings from the vertex (P13 potential and N40 potential) and neck musculature (SR) showed that (1) in a prepulse paradigm, increasing the intensity of the prepulse or decreasing the interstimulus interval resulted in increased inhibition of the P13 potential, N40 potential (to a lesser degree) and the SR (to a greater degree), (2) when using a low signal-to-noise ratio between the prepulse intensity and the background level, prepulse inhibition of the SR was reduced or absent while that of the P13 potential was present, (3) the amplitude of the 'prepulse evoked' P13 potential was significantly correlated with prepulse inhibition of the Pla potential, the N40 potential and the SR (4) in a paired identical stimulus paradigm, decreasing the interstimulus interval resulted in increased habituation of the P13 potential, N40 potential (to a lesser degree) and the SR, and (5) increasingthe intensity of the paired stimulation resulted in increased habituation of the P13 potential and the N40 potential (to a lesser degree), but not ofthe SR. These results demonstrate the presence of prepulse inhibition of the P13 potential, the N40 potential and the SR in a parallel manner, but show certain specific differences in their responses to parametric changes. (C) 1999 Elsevier Science B.V. AU rights reserved.

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Documento generato il 22/01/20 alle ore 12:58:43