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Titolo:
Rectifying effect of exercise on hypertension in spontaneously hypertensive rats via a calcium-dependent dopamine synthesizing system in the brain
Autore:
Akiyama, K; Sutoo, D;
Indirizzi:
Univ Tsukuba, Inst Med Sci, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 823, anno: 1999,
pagine: 154 - 160
SICI:
0006-8993(19990327)823:1-2<154:REOEOH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; POSTEXERCISE HYPOTENSION; SUBSTITUTED BENZAMIDE; RECEPTORS; ATTENUATION; MECHANISMS; MODULATION;
Keywords:
blood pressure; calcium/calmodulin; dopamine receptor; dopamine synthesis in brain; exercise; spontaneously hypertensive rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sutoo, D Univ Tsukuba, Inst Med Sci, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 baraki 3058575, Japan
Citazione:
K. Akiyama e D. Sutoo, "Rectifying effect of exercise on hypertension in spontaneously hypertensive rats via a calcium-dependent dopamine synthesizing system in the brain", BRAIN RES, 823(1-2), 1999, pp. 154-160

Abstract

The effect of exercise on blood pressure in spontaneously hypertensive rats (SHR) was investigated assuming a mechanism involving calcium-dependent dopamine synthesis in the brain. Male SHR (13 weeks of age) were forced to run for 1 h at a speed of 10 m/min using a programmed motor-driven wheel cage. Systolic blood pressure was reduced after running, and this effect of exercise was decreased by prior intracerebroventricular administration of EDTA (1 nmol/rat), alpha-methyltyrosine (inhibitor of tyrosine hydroxylase, I mg/rat), sulpiride (D-2 receptor antagonist, 50 mu g/rat) or eticlopride (D-2 receptor antagonist, 100 mu g/rat), but was not changed by administration of SCH 23390 (D-1 receptor antagonist, 30 mu g/rat). Also, the calcium levels in the serum and brain were increased by exercise. Combining these results with our previous reports, it is suggested that exercise leads to an increase in the serum calcium level and subsequently an increase in the brain calcium level. This, in turn, leads to increased brain dopamine synthesisthrough a calmodulin-dependent system, with the increased dopamine levels inhibiting sympathetic nerve activity via the dopamine D-2 receptor in the brain and causing a reduction in blood pressure. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:32:33