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Titolo:
The neural consequences of conflict between intention and the senses
Autore:
Fink, GR; Marshall, JC; Halligan, PW; Frith, CD; Driver, J; Frackowiak, RSJ; Dolan, RJ;
Indirizzi:
Univ Dusseldorf, Neurol Klin, D-40001 Dusseldorf, Germany Univ DusseldorfDusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany Inst Neurol, Wellcome Dept Cognit Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nit Neurol, London WC1N 3BG, England Univ Coll London, London, England Univ Coll London London EnglandUniv Coll London, London, England Royal Free Hosp, Sch Med, London, England Royal Free Hosp London England oyal Free Hosp, Sch Med, London, England UnivOX2ford, Radcliffe Infirm, Dept Clin Neurol, Neuropsychol Unit, OxfordUniv Oxford Oxford England OX2 6HE lin Neurol, Neuropsychol Unit, Oxford KFA Julich GmbH, Forschungszentrum, Inst Med, Julich, Germany KFA Julich GmbH Julich Germany chungszentrum, Inst Med, Julich, Germany Dept Expt Psychol, Oxford OX1 3UD, England Dept Expt Psychol Oxford England OX1 3UD sychol, Oxford OX1 3UD, England
Titolo Testata:
BRAIN
, volume: 122, anno: 1999,
parte:, 3
pagine: 497 - 512
SICI:
0006-8950(199903)122:<497:TNCOCB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DORSOLATERAL FRONTAL-CORTEX; POSTERIOR PARIETAL CORTEX; SPATIAL WORKING-MEMORY; PREFRONTAL CORTEX; VISUAL-ATTENTION; MOTOR AREAS; BRAIN; SPACE; PET;
Keywords:
prefrontal cortex; sensorimotor integration; PET; monitoring; Luria's bimanual co-ordination task;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Fink, GR UnivyDusseldorf, Neurol Klin, Postfach 10 10 07, D-40001 Dusseldorf, German Univ Dusseldorf Postfach 10 10 07 Dusseldorf Germany D-40001 man
Citazione:
G.R. Fink et al., "The neural consequences of conflict between intention and the senses", BRAIN, 122, 1999, pp. 497-512

Abstract

Normal sensorimotor states involve integration of intention, action and sensory feedback. An example is the congruence between motor intention and sensory experience (both proprioceptive and visual) when we move a limb through space, Such goal-directed action necessitates a mechanism that monitors sensorimotor inputs to ensure that motor outputs are congruent with currentintentions. Monitoring in this sense is usually implicit and automatic butbecomes conscious whenever there is a mismatch between expected and realized sensorimotor states. To investigate how the latter type of monitoring isachieved we conducted three fully factorial functional neuroimaging experiments using PET measures of relative regional cerebral blood flow with healthy volunteers. In the first experiment subjects were asked to perform Luria's bimanual co-ordination task which involves either in-phase (conditions 1 and 3) or out-of-phase (conditions 2 and 4) bimanual movements (factor one), while looking towards their left hand. In half of the conditions (conditions 3 and 4) a mirror was used that altered visual feedback (factor two) by replacing their left hand with the mirror image of their right hand. Hence (in the critical condition 4) subjects saw in-phase movements despite performing out-of-phase movements. This mismatch between intention, proprioception and visual feedback engendered cognitive conflict, The main effect ofout-of-phase movements was associated with increased neural activity in posterior parietal cortex (PPC) bilaterally [Brodmann area (BA) 40, extendinginto BA 7] and dorsolateral prefrontal cortex (DLPFC) bilaterally (BA 9/46). The main effect of the mirror showed increased neural activity in right DLPFC (BA 9/46) and right superior PPC (BA 7) only, Analysis of the critical interaction revealed that the mismatch condition led to a specific activation in the right DLPFC alone (BA 9/46). Study 2, using an identical experimental setup but manipulating visual feedback from the right hand (instead of the left), subsequently demonstrated that this right DLPFC activation was independent of the hand attended. Finally, study 3 removed the motor intentional component by moving the subjects' hand passively, thus engendering a mismatch between proprioception and vision only. Activation in the right lateral prefrontal cortex was now more ventral than in studies 1 or 2 (BA 44/45). A direct comparison of studies 1 and 3 (which both manipulated visual feedback from the left hand) confirmed that a ventral right lateral prefrontal region is primarily activated by discrepancies between signals from sensory systems, while a more dorsal area in right lateral prefrontal cortexis activated when actions must be maintained in the face of a conflict between intention and sensory outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:35:01