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Titolo:
Prostaglandin D-2 and sleep regulation
Autore:
Urade, Y; Hayaishi, O;
Indirizzi:
Osaka Biosci Inst, Dept Mol Behav Biol, Osaka 5650874, Japan Osaka Biosci Inst Osaka Japan 5650874 l Behav Biol, Osaka 5650874, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 3, volume: 1436, anno: 1999,
pagine: 606 - 615
SICI:
1388-1981(19990104)1436:3<606:PDASR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CEREBROSPINAL-FLUID; SYNTHASE BETA-TRACE; CYTOSOLIC PHOSPHOLIPASE A(2); RETINOL-BINDING-PROTEIN; RAT-BRAIN; D SYNTHETASE; MAST-CELLS; CHOROID-PLEXUS; GENE-EXPRESSION; MESSENGER-RNA;
Keywords:
sleep; prostaglandin D-2; prostaglandin D synthase; beta-trace; cerebrospinal fluid; DP receptor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Urade, Y OsakanBiosci Inst, Dept Mol Behav Biol, 6-2-4 Furuedai, Osaka 5650874, Japa Osaka Biosci Inst 6-2-4 Furuedai Osaka Japan 5650874 50874, Japa
Citazione:
Y. Urade e O. Hayaishi, "Prostaglandin D-2 and sleep regulation", BBA-MOL C B, 1436(3), 1999, pp. 606-615

Abstract

Prostaglandin (PG) D-2 is recognized as the most potent endogenous sleep-promoting substance whose action mechanism is the best characterized among the various sleep-substances thus far reported. The PGD(2) concentration in rat cerebrospinal fluid (CSF) shows a circadian change coupled to the sleep-wake cycle and elevates with an increase in sleep propensity during sleep deprivation. Lipocalin-type PGD synthase is dominantly produced in the arachnoid membrane and choroid plexus of the brain, and is secreted into the CSF to become beta-trace, a major protein component of the CSF. The PGD synthase as well as the PGD(2) thus produced circulates in the ventricular system, subarachnoidal space, and extracellular space in the brain system. PGD(2) then interacts with DP receptors in the chemosensory region of the ventro-medial surface of the rostral basal I forebrain to initiate the signal to promote sleep probably via the activation of adenosine A(2A) receptive neurons. The I activation of DP receptors in the PGD(2)-sensitive chemosensory region results in activation of a cluster of neurons within the ventrolateral preoptic area, which may promote sleep by inhibiting tuberomammillary nucleus, the source of the ascending histaminergic arousal system. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:24:19