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Titolo:
Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV after cessation of duodenal fat infusion: mediation by bile
Autore:
Kalogeris, TJ; Fukagawa, K; Tsuchiya, T; Qin, XF; Tso, P;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Surg, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 rg, Shreveport, LA 71130 USA Louisiana71130e Univ, Med Ctr, Dept Mol & Cellular Physiol, Shreveport, LALouisiana State Univ Shreveport LA USA 71130 ular Physiol, Shreveport, LA Univ Cincinnati, Dept Pathol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Pathol, Cincinnati, OH 45267 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 3, volume: 1436, anno: 1999,
pagine: 451 - 466
SICI:
1388-1981(19990104)1436:3<451:ISALSO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT MESENTERIC LYMPH; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; LIPID ABSORPTION; FEEDING-BEHAVIOR; SELF-ASSOCIATION; GENE-EXPRESSION; HUMAN-PLASMA; TRANSPORT; LIPOPROTEINS; TRIGLYCERIDE;
Keywords:
lymph; triacylglycerol; bile diversion; nutrient absorption; chylomicron; apolipoprotein A-IV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kalogeris, TJ LouisianaAState Univ, Med Ctr, Dept Surg, 1501 Kings Highway, Shreveport, L Louisiana State Univ 1501 Kings Highway Shreveport LA USA 71130
Citazione:
T.J. Kalogeris et al., "Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV after cessation of duodenal fat infusion: mediation by bile", BBA-MOL C B, 1436(3), 1999, pp. 451-466

Abstract

We tested whether secretion of apolipoprotein (apo) A-IV depends upon intestinal triglyceride (TG) transport by comparing output kinetics of TG and apo A-IV during and after duodenal lipid infusion in lymph-fistula rats. Lipid infusion (triolein. 40 mu mol/h, 8 h) produced increases in lymphatic TGand apo A-IV output. After 8 h, triolein infusate was replaced with glucose-saline; TG output returned to basal levels 4-5 h later. However, apo A-IVoutput continued at significantly elevated levels until 20 h after the start of the experiment. Bile diversion blocked this continued output of A-IV during the post-lipid period, and resulted in basal TG output that was 75% lower than in bile-intact rats. Return of bile or low-dose triolein infusion (5 mu mol/h) into the intestine reversed these effects, There were no differences in hepatic synthesis or filtration of plasma A-IV into lymph between bile-intact and bile-diverted groups. Intestinal A-IV synthesis was elevated in both groups even during the post-lipid period. The results support the hypothesis that intestinal triglyceride transport drives apo A-IV secretion, and suggest the existence of a bile-dependent, post-translational mechanism for the control of lymphatic apo A-IV output. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/04/20 alle ore 01:41:16