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Titolo:
There a case for DHEA replacement?
Autore:
Nippoldt, TB; Nair, KS;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Metab Endocrinol & Nutr, Rochester, MN 55905 USAMayo Clin & Mayo Fdn Rochester MN USA 55905 Nutr, Rochester, MN 55905 USA
Titolo Testata:
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 12, anno: 1998,
pagine: 507 - 520
SICI:
0950-351X(199810)12:3<507:TACFDR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROEPIANDROSTERONE-SULFATE; POSTMENOPAUSAL WOMEN; MYOCARDIAL-INFARCTION; ALZHEIMERS-DISEASE; BREAST-CANCER; SERUM LEVELS; ORAL DEHYDROEPIANDROSTERONE; CARDIOVASCULAR-DISEASE; CALORIE RESTRICTION; FOOD RESTRICTION;
Keywords:
DHEA; DHEA-S; ageing; sarcopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Nair, KS Mayo,Clin & Mayo Fdn, Div Metab Endocrinol & Nutr, 200 1st St SW,Rochester Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 chester
Citazione:
T.B. Nippoldt e K.S. Nair, "There a case for DHEA replacement?", BAIL CLIN E, 12(3), 1998, pp. 507-520

Abstract

There are many hormonal changes that occur with ageing in humans, of whichthe most dramatic and intriguing change occurs for the adrenal androgenic steroid dehydroepiandosterone (DHEA). There are tantalizing epidemiologicaldata demonstrating a significant association between the changes in circulating DHEA level and changes in the incidence of malignancy, atherosclerosis, Alzheimer's disease and other age-related changes. The pharmacological effects in animals such as rodents and rabbits have demonstrated many beneficial effects, for example increased immune function, the prevention of atherosclerosis, cancer, diabetes and obesity, and the improvement of memory. Clinical studies carried out in small groups of subjects have clearly demonstrated that the administration of DHEA to the elderly increases many hormone levels, including that of insulinlike growth factor-1, (free and total) testosterone, dihydrotestosterone, oestrone and oestradiol. It remains to beclearly defined whether these changes are clinically beneficial, and thereis only insufficient information on the side-effects on long-term use. Results from short-term intervention studies in small groups of subjects have not demonstrated any convincing beneficial effects so far. A judgement on whether DHEA replacement has a place in preventing age-related disabilities could be determined only on the basis of results from studies of long-term DHEA replacement in elderly people.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:12:57