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Titolo:
Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov
Autore:
Elsen, JM; Amigues, Y; Schelcher, F; Ducrocq, V; Andreoletti, O; Eychenne, F; Khang, JVT; Poivey, JP; Lantier, F; Laplanche, JL;
Indirizzi:
INRA, SAGA, F-31326 Auzeville, France INRA Auzeville France F-31326INRA, SAGA, F-31326 Auzeville, France LABOGENA, Jouy En Josas, France LABOGENA Jouy En Josas FranceLABOGENA, Jouy En Josas, France Ecole Natl Vet, Toulouse, France Ecole Natl Vet Toulouse FranceEcole Natl Vet, Toulouse, France INRA, SGQA, Jouy En Josas, France INRA Jouy En Josas FranceINRA, SGQA, Jouy En Josas, France INRA, PII, Nouzilly, France INRA Nouzilly FranceINRA, PII, Nouzilly, France Fac Pharm, Biol Cellulaire Lab, Paris, France Fac Pharm Paris FranceFac Pharm, Biol Cellulaire Lab, Paris, France
Titolo Testata:
ARCHIVES OF VIROLOGY
fascicolo: 3, volume: 144, anno: 1999,
pagine: 431 - 445
SICI:
0304-8608(1999)144:3<431:GSATFI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL SCRAPIE; PRP GENOTYPE; SPONGIFORM ENCEPHALOPATHY; MATERNAL TRANSMISSION; EMBRYO-TRANSFER; SHEEP; POLYMORPHISMS; SUFFOLK; ALLELES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Elsen, JM INRA, SAGA, BP 27, F-31326 Auzeville, France INRA BP 27 Auzeville France F-31326 , F-31326 Auzeville, France
Citazione:
J.M. Elsen et al., "Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov", ARCH VIROL, 144(3), 1999, pp. 431-445

Abstract

Information from a scrapie epidemic in a closed INRA Romanov flock is presented. Performances, pedigree, histopathological diagnoses and PrP genotypes were recorded from the beginning of the outbreak (in 1993). Between I st of April, 1993 and I st of May, 1997, 1015 animals were exposed to scrapie,and 304 died from this disease. A major influence of the polymorphisms at codons 136, 154 and 171 is shown, A(136)H(153)Q(171) allele carriers proving to be nearly as resistant as A(136)R(154)R(171) carriers. A possible relationship between gastrointestinal parasitism and scrapie is discussed. There is evidence of maternal transmission, with a risk; ratio for artificiallyfed lambs of 67 percent of the risk of lambs fed by their mother. Our results strongly suggest that resistant animals were not healthy carriers or atleast were less infectious when comparing risk for lambs born to healthy dams either of resistant (risk = 0.431) or of susceptible (risk = 1.000) genotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:48:21