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Titolo:
Synaptic mechanisms for coding timing in auditory neurons
Autore:
Trussell, LO;
Indirizzi:
Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Physiol, Madison, WI 53706 USA
Titolo Testata:
ANNUAL REVIEW OF PHYSIOLOGY
, volume: 61, anno: 1999,
pagine: 477 - 496
SICI:
0066-4278(1999)61:<477:SMFCTI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTEROVENTRAL COCHLEAR NUCLEUS; GLUTAMATE-RECEPTOR SUBUNITS; RAT MEDIAL NUCLEUS; EXCITATORY POSTSYNAPTIC CURRENTS; DIFFERENTIAL EXPRESSION PATTERNS; INTERAURAL TIME SENSITIVITY; VOLTAGE-CLAMP ANALYSIS; SPIRAL GANGLION-CELLS; NON-NMDA RECEPTORS; AMPA RECEPTORS;
Keywords:
glutamate receptors; potassium channels; synapses; plasticity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Trussell, LO Univ Wisconsin, Dept Physiol, 1300 Univ Ave, Madison, WI 53706 USA Univ Wisconsin 1300 Univ Ave Madison WI USA 53706 I 53706 USA
Citazione:
L.O. Trussell, "Synaptic mechanisms for coding timing in auditory neurons", ANN R PHYSL, 61, 1999, pp. 477-496

Abstract

Neurons in the cochlear ganglion and auditory brain stem nuclei preserve the relative timing of action potentials passed through sequential synaptic levels. To accomplish this task, these neurons have unique morphological and biophysical specializations in axons, dendrites, and nerve terminals. At the membrane level, these adaptations include low-threshold, voltage-gated potassium channels and unusually rapid-acting transmitter-gated channels, which govern how quickly and reliably action potential threshold is reached during a synaptic response. Some nerve terminals are remarkably large and release large amounts of excitatory neurotransmitter. The high output of transmitter at these terminals can lead to synaptic depression, which may itself be regulated by presynaptic transmitter receptors. The way in which these different cellular mechanisms are employed varies in different cell typesand circuits and reflects refinements suited to different aspects of acoustic processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:35:27