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Titolo:
Regulation of natriuretic peptide secretion by the heart
Autore:
Thibault, G; Amiri, F; Garcia, R;
Indirizzi:
Clindaes Inst Montreal, Lab Cell Biol Hypertens, Montreal, PQ H2W 1R7, Cana Clin Res Inst Montreal Montreal PQ Canada H2W 1R7 treal, PQ H2W 1R7, Cana ClinH2Ws Inst Montreal, Lab Expt Hyperten & Vasoact Peptides, Montreal, PQClin Res Inst Montreal Montreal PQ Canada H2W 1R7 Peptides, Montreal, PQ Univ Montreal, Montreal, PQ H2W 1R7, Canada Univ Montreal Montreal PQ Canada H2W 1R7 al, Montreal, PQ H2W 1R7, Canada
Titolo Testata:
ANNUAL REVIEW OF PHYSIOLOGY
, volume: 61, anno: 1999,
pagine: 193 - 217
SICI:
0066-4278(1999)61:<193:RONPSB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CULTURED RAT ATRIAL; CORTICOTROPIN-RELEASING FACTOR; STRETCH-INDUCED RELEASE; GENE-RELATED PEPTIDE; ANGIOTENSIN-II; ANP SECRETION; VENTRICULAR MYOCARDIUM; MECHANICAL STRETCH; INDUCED INCREASE;
Keywords:
atrial stretch; endothelin; alpha(1)-adrenergic agonists; intracellular calcium; prostaglandins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Thibault, G ClinPQes Inst Montreal, Lab Cell Biol Hypertens, 110 Pine Ave W, Montreal, Clin Res Inst Montreal 110 Pine Ave W Montreal PQ Canada H2W 1R7
Citazione:
G. Thibault et al., "Regulation of natriuretic peptide secretion by the heart", ANN R PHYSL, 61, 1999, pp. 193-217

Abstract

Secreted by the heart, more specifically by atrial cardiomyocytes under normal conditions but also by ventricular myocytes during cardiac hypertrophy, natriuretic peptides are now considered important hormones in the controlof blood pressure and salt and water excretion. Studies on natriuretic peptide secretagogues and their mechanisms of action have been complicated by hemodynamic changes and contractions to which the atria are constantly subjected. It now appears that atrial stretch through mechano-sensitive ion channels, adrenergic stimulation via alpha(1A)-adrenergic receptors, and endothelin via its ETA receptor subtype are major triggering agents of natriuretic peptide release. With several other stimuli, such as angiotensin II and beta-adrenergic agents, modulation of natriuretic peptide release appears to be Linked to local generation of prostaglandins. In all cases, intracellular calcium homeostasis, controlled by several ion channels, is considered a key element in the regulation of natriuretic peptide secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:05:08