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Titolo:
Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background
Autore:
Bowers, BJ; Owen, EH; Collins, AC; Abeliovich, A; Tonegawa, S; Wehner, JM;
Indirizzi:
Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA Univ Colorado, Dept Psychol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 o, Dept Psychol, Boulder, CO 80309 USA MIT, Ctr Learning & Memory, Cambridge, England MIT Cambridge EnglandMIT, Ctr Learning & Memory, Cambridge, England
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 3, volume: 23, anno: 1999,
pagine: 387 - 397
SICI:
0145-6008(199903)23:3<387:DESATD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; CEREBELLAR GRANULE CELLS; RECOMBINANT INBRED MICE; QUANTITATIVE TRAIT LOCI; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; INITIAL SENSITIVITY; XENOPUS-OOCYTES; INDUCED HYPOTHERMIA; MOTOR IMPAIRMENT;
Keywords:
ethanol tolerance; initial sensitivity; gamma-protein kinase C; null mutant mice; genetic background;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Wehner, JM Univ Colorado, Inst Behav Genet, Campus Box 447, Boulder, CO 80309 USA Univ Colorado Campus Box 447 Boulder CO USA 80309 CO 80309 USA
Citazione:
B.J. Bowers et al., "Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background", ALC CLIN EX, 23(3), 1999, pp. 387-397

Abstract

Initial sensitivity and tolerance development to the sedative-hypnotic andhypothermic effects of ethanol were investigated in gamma-protein kinase C(PKC) null mutant mice. Null mutants from a C57BL/6J x 129/SvJ mixed genetic background demonstrated decreased ethanol sensitivity and failed to develop chronic tolerance after 10 days of ethanol liquid diet. However, when the null mutation was introgressed onto a C57BL/6J background for six generations, the "no tolerance" phenotype for sedative-hypnotic and hypothermic effects of ethanol was no longer apparent. Outcrossing the gamma-PKC null mutation to a C57BL/6J x 129/SvEvTac mixed background restored the "no tolerance" phenotype to ethanol-induced sedation after chronic ethanol diet; however, as measured by hypothermia, tolerance was still evident in the null mutant mice. These observations and the results of tests of chronic tolerancein the C57BL/6J, 129/SvJ, and 129/SvEvTac background inbred strains indicate that gamma-PKC plays an important role in initial sensitivity and tolerance to ethanol. However, the impact of gamma-PKC is modulated by the background genotype. These results stress the importance of including the effect of genetic background when evaluating the effects of single gene mutations on quantitative behavioral traits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:05:13