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Titolo:
Streptococcus equi but not Streptococcus zooepidemicus produces potent mitogenic responses from equine peripheral blood mononuclear cells
Autore:
Anzai, T; Sheoran, AS; Kuwamoto, Y; Kondo, T; Wada, R; Inoue, T; Timoney, JF;
Indirizzi:
Univ Kentucky, Dept Vet Sci, Gluck Equine Res Ctr, Lexington, KY 40546 USAUniv Kentucky Lexington KY USA 40546 ine Res Ctr, Lexington, KY 40546 USA Japan9041,ng Assoc, Equine Res Inst, Epizoot Res Stn, Kokubunji, Tochigi 32 Japan Racing Assoc Kokubunji Tochigi Japan 329041 , Kokubunji, Tochigi 32 Yamaguchi Univ, Fac Agr, Dept Vet Hyg, Yamaguchi 753, Japan Yamaguchi Univ Yamaguchi Japan 753 r, Dept Vet Hyg, Yamaguchi 753, Japan
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 3, volume: 67, anno: 1999,
pagine: 235 - 246
SICI:
0165-2427(19990222)67:3<235:SEBNSZ>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXIC-SHOCK-SYNDROME; M-PROTEIN; SUBSP EQUI; GROUP-C; SUPERANTIGENS; SURVIVAL; INDUCERS; PYOGENES; DISEASE; HORSES;
Keywords:
Streptococcus equi; Streptococcus zooepidemicus; strangles; mitogen; mitogenicity; mitogenic response; culture supernatant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Timoney, JF Univ Kentucky, Dept Vet Sci, Gluck Equine Res Ctr, Lexington, KY 40546 USA Univ Kentucky Lexington KY USA 40546 Lexington, KY 40546 USA
Citazione:
T. Anzai et al., "Streptococcus equi but not Streptococcus zooepidemicus produces potent mitogenic responses from equine peripheral blood mononuclear cells", VET IMMUNOL, 67(3), 1999, pp. 235-246

Abstract

Streptococcus equi causes equine strangles. The acute disease has many of the hallmarks of an acute response including high fever, elevated plasma fibrinogen and neutrophilia, affects known to be mediated by proinflammatory cytokines. The objective of this study was to screen-culture supernatants from equine clinical isolates of S. equi and S. zooepidemicus for stimulation of mitogenic responses by horse peripheral blood mononuclear cells. Mitogenicity comparable to that of concanavalin A was detected in culture supernatants of S, equi strains but not in those of S. zooepidemicus. Mitogenicity was neutralised by Proteinase K and a post-strangles convalescent serum, and evidence for the presence of both thermo-resistant and thermo-labile mitogenic factors was obtained. Release of proteinaceous immunogenic mitogensin combination with the antiphagocytic protein SeM unique to S. equi may therefore contribute to some of the severe clinical manifestations of acute strangles in the horse. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:50:29