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Titolo:
Blockade of nicotine self-administration with nicotinic antagonists in rats
Autore:
Watkins, SS; Epping-Jordan, MP; Koob, GF; Markou, A;
Indirizzi:
ScrippsSAlin & Res Fdn, Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 U Scripps Clin & Res Fdn La Jolla CA USA 92037 rmacol, La Jolla, CA 92037 U Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 sychol, La Jolla, CA 92093 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 62, anno: 1999,
pagine: 743 - 751
SICI:
0091-3057(199904)62:4<743:BONSWN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDRO-BETA-ERYTHROIDINE; VENTRAL TEGMENTAL AREA; CIGARETTE-SMOKING; ABSTINENCE SYNDROME; COCAINE; MECAMYLAMINE; INJECTIONS; WITHDRAWAL; SCHEDULES; RECEPTORS;
Keywords:
nicotine; self-administration; reinforcement; mecamylamine; dihydro-beta-erythroidine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Markou, A Scripps Clin & Res Fdn, Res Inst, Dept Neuropharmacol, CVN-7,10550 N Torrey Scripps Clin & Res Fdn CVN-7,10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
S.S. Watkins et al., "Blockade of nicotine self-administration with nicotinic antagonists in rats", PHARM BIO B, 62(4), 1999, pp. 743-751

Abstract

The reinforcing properties of a variety of drugs abused by humans have been investigated using the technique of intravenous self-administration in the rat. To examine the effect of nicotine dose on nicotine self-administration, Wistar rats were allowed to self-administer various doses of nicotine using a within-subjects Latin square design. An inverted U-shaped dose-response curve was obtained, with the highest rates of responding at the 0.03 mg/kg/inf dose. With I-h daily nicotine sell-administration sessions, rats did not appear dependent on nicotine 24 h later, as indicated by the absence of somatic signs of withdrawal after subcutaneous injection of a nicotinic acetylcholine receptor antagonist, mecamylamine (0.57 mg/kg). In another set of studies, pretreatment with subcutaneous mecamylamine or dihydro-beta-erythroidine, two nicotinic acetylcholine receptor antagonists, resulted in significant dose-dependent reductions in nicotine self-administration, at two nicotine doses (0.03 and 0.06 mg/kg/inf). These results indicate that nicotine is an effective reinforcer in Wistar rats under the present parameters, and that these reinforcing effects are mediated by activation of nicotinic acetylcholine receptors. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:10:17