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Titolo:
Discriminative stimulus properties of ethanol in rats: Studies on the roleof nitric oxide
Autore:
Koros, E; Kostowski, W; Bienkowski, P;
Indirizzi:
Instsaw,chiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 War Inst Psychiat & Neurol Warsaw Poland PL-02957 Nervous Syst, PL-02957 War Med Acad Warsaw, Dept Expt & Clin Pharmacol, Warsaw, Poland Med Acad Warsaw Warsaw Poland ept Expt & Clin Pharmacol, Warsaw, Poland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 62, anno: 1999,
pagine: 607 - 612
SICI:
0091-3057(199904)62:4<607:DSPOEI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; L-ARGININE; RECEPTOR ANTAGONIST; CORTICAL-NEURONS; SYNTHASE; INHIBITION; 7-NITROINDAZOLE; POTENTIATION; CONSUMPTION; INVOLVEMENT;
Keywords:
ethanol; nitric oxide; drug discrimination; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bienkowski, P Instgosychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, Al Sobieskie Inst Psychiat & Neurol Al Sobieskiego 1-9 Warsaw Poland PL-02957
Citazione:
E. Koros et al., "Discriminative stimulus properties of ethanol in rats: Studies on the roleof nitric oxide", PHARM BIO B, 62(4), 1999, pp. 607-612

Abstract

The present study examined the role of the L-arginine-nitric oxide pathwayin mediation of the ethanol interoceptive (discriminative) cue. Adult maleWistar rats (n = 16) were trained to discriminate ethanol (1 g/kg, 10% v/v) from saline under a fixed-ratio 10 (FR10) schedule of sweetened milk reinforcement. A nonselective nitric oxide synthase (NOS) inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME; 10-540 mg/kg) did not substitute for ethanol. Similarly, a relatively selective neuronal NOS inhibitor, 7-nitroindazole (7-NI; 10-80 mg/kg), did not mimic the ethanol cue. However, both L-NAMEand 7-NI produced significant reduction in the rate of operant responding. A nitric oxide precursor, L-arginine (100-500 mg/kg) neither substituted for nor antagonize the ethanol stimulus. Taken together, these results suggest that the L-arginine-nitric oxide pathway is not involved in mediation ofthe discriminative stimulus effects of ethanol in the rat. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:12:35