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Titolo:
Effects of chronic antidepressants in an operant conflict procedure of anxiety in the rat
Autore:
Beaufour, CC; Ballon, N; Le Bihan, C; Hamon, M; Thiebot, MH;
Indirizzi:
Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere, Dept Pharmacol, F-75634 Paris, France Fac Med Pitie Salpetriere Paris France F-75634 ol, F-75634 Paris, France
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 62, anno: 1999,
pagine: 591 - 599
SICI:
0091-3057(199904)62:4<591:EOCAIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC IMIPRAMINE; FOOD RESTRICTION; ANIMAL-MODEL; H-3 NORADRENALINE; SOCIAL-BEHAVIOR; 5-HT2 RECEPTORS; PANIC DISORDER; UPTAKE SITES; DRUGS; MICE;
Keywords:
anxiety; chronic treatment; conditioned behavioral suppression; desipramine; fluoxetine; imipramine; maprotiline; phenelzine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Beaufour, CC Facnced Pitie Salpetriere, INSERM, U288, 91 Blvd Hop, F-75634Paris 13, Fra Fac Med Pitie Salpetriere 91 Blvd Hop Paris France 13 3, Fra
Citazione:
C.C. Beaufour et al., "Effects of chronic antidepressants in an operant conflict procedure of anxiety in the rat", PHARM BIO B, 62(4), 1999, pp. 591-599

Abstract

The effects of chronic antidepressants were investigated in an animal procedure for the study of anxiety and anxiolytics, the conditioned suppressionof operant behavior in rats. In daily 18-min sessions, three periods of nonpunished lever pressing for food alternated with two 4-min periods signaled by a light-on conditioned stimulus during which 50% of the responses wererandomly punished by electric foot, shocks. Antidepressants were administered once daily for 7-8 weeks to trained, food-restricted rats. Desipramine(dose regimen increase from 4 to 16 mg/kg/day) induced a gradual (4-5-week latency) release of response suppression during punished periods over the course of several weeks of testing. This anxiolytic-like effect was still present 3 weeks following drug discontinuation. In contrast, chronic imipramine (dose regimen increase from 4 to 16 mg/kg/day), maprotiline (4 to 16 mg/kg/day), phenelzine (2 to 4 mg/kg/day), and fluoxetine (1 or 8 mg/kg/day; constant dose), resulted in no change in punished responding, suggesting thatno anxiolytic-like effect developed in the course of chronic treatment with these compounds. The largest dose of all antidepressants studied (except fluoxetine) induced a moderate to marked reduction of nonpunished performance that disappeared within 1 week after the last injection. A transient release of conditioned response suppression emerged during the week that followed discontinuation of imipramine, maprotiline, and fluoxetine (8 mg/kg/day). This apparent anxiolytic-like activity might be due to a reduction of some adverse effect induced by the high doses used, and/or might have resulted from a new dynamic equilibrium between monoamine release, reuptake processes, and sensitivity of postsynaptic receptors. In conclusion, operant conflict procedures in rats seem not particularly able to model human anxiety sensitive to chronic antidepressant treatments. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:50:17