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Titolo:
Effects of zinc acexamate (NAS-501) on superoxide radicals and lipid peroxidation of rat gastric mucosa
Autore:
Tsutsui, Y; Nakamura, Y; Yamaguchi, S; Kawanaka, N; Sato, M;
Indirizzi:
Nissho Corp, Pharmaceut Res Ctr, Osaka 5660055, Japan Nissho Corp Osaka Japan 5660055 Pharmaceut Res Ctr, Osaka 5660055, Japan
Titolo Testata:
PHARMACOLOGY
fascicolo: 4, volume: 58, anno: 1999,
pagine: 209 - 219
SICI:
0031-7012(199904)58:4<209:EOZA(O>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-FREE RADICALS; CAMPYLOBACTER-PYLORIDIS; HUMAN-NEUTROPHILS; CELLS; MACROPHAGES; DAMAGE;
Keywords:
zinc acexamate; superoxide radical; lipid peroxidation; acute gastric mucosal injury; inflammatory cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutsui, Y Nissho Corp, Pharmaceut Res Ctr, 2-32-4 Shinzaike, Osaka 5660055, Japan Nissho Corp 2-32-4 Shinzaike Osaka Japan 5660055 660055, Japan
Citazione:
Y. Tsutsui et al., "Effects of zinc acexamate (NAS-501) on superoxide radicals and lipid peroxidation of rat gastric mucosa", PHARMACOL, 58(4), 1999, pp. 209-219

Abstract

Zinc acexamate (NAS-501), an anti-ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and duodenal ulcers inrats. In order to clarify the mechanisms by which NAS-501 exhibits the anti-ulcer effects, we investigated the anti-oxidative effects of NAS-501 in vitro and in vivo. NAS-501 significantly reduced the superoxide radical-dependent chemiluminescence, generated by hypoxanthine-xanthine oxidase, rat neutrophils and guinea-pig macrophages in vitro. These in vitro effects were also confirmed by electron spin resonance using a 5,5-dimethyl-1-pyrroline-N-oxide spin-trapping method. In addition, NAS-501 significantly inhibited lipid peroxidation induced by increasing concentrations of Fe2+/ascorbate in rat gastric mucosal homogenate in vitro. Oral administration of NAS-501 (30 mg/kg) significantly inhibited production of thiobarbituric acid-reactive substance in rat gastric mucosa following per os instillation of 60% ethanol in 150 mmol/l HCl in vivo. These results suggest that NAS-501 exhibits the preventive effect from acute gastric mucosal lesions by the anti-oxidative activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:34:15