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Titolo:
Refined mapping of the region of loss of heterozygosity on the long arm ofchromosome 7 in human breast cancer defines the location of a second tumorsuppressor gene at 7q22 in the region of the CUTL1 gene
Autore:
Zeng, WR; Watson, P; Lin, J; Jothy, S; Lidereau, R; Park, M; Nepveu, A;
Indirizzi:
McGill Univ, Mol Oncol Grp, Dept Med, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Oncol Grp, Dept Med, Montreal, PQ, Canada McGill Univ, Mol Oncol Grp, Dept Oncol, Montreal, PQ, Canada McGill Univ Montreal PQ Canada col Grp, Dept Oncol, Montreal, PQ, Canada Univ Manitoba, Fac Med, Dept Pathol & Physiol, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 ol, Winnipeg, MB R3T 2N2, Canada Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Lab Med & Pathobiol, Toronto, ON, Canada Ctr Rene Huguenin, Lab Oncogenet, F-92211 St Cloud, France Ctr Rene Huguenin St Cloud France F-92211 enet, F-92211 St Cloud, France
Titolo Testata:
ONCOGENE
fascicolo: 11, volume: 18, anno: 1999,
pagine: 2015 - 2021
SICI:
0950-9232(19990318)18:11<2015:RMOTRO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CCAAT DISPLACEMENT PROTEIN; HOMEODOMAIN PROTEIN; UTERINE LEIOMYOMATA; DROSOPHILA CUT; SUSCEPTIBILITY; EXPRESSION; PROMOTER; DELETION; 7Q31; LOCALIZATION;
Keywords:
breast cancer; tumor suppressor gene; chromosome 7q22; CUTL1; human Cut homeobox gene; loss of heterozygosity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Nepveu, A McGill Univ, Mol Oncol Grp, Dept Med, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Dept Med, Montreal, PQ, Canada
Citazione:
W.R. Zeng et al., "Refined mapping of the region of loss of heterozygosity on the long arm ofchromosome 7 in human breast cancer defines the location of a second tumorsuppressor gene at 7q22 in the region of the CUTL1 gene", ONCOGENE, 18(11), 1999, pp. 2015-2021

Abstract

In breast cancer, loss of heterozygosity (LOH) has been described on the long arm of chromosome 7, at band q31, suggesting the presence of a tumor suppressor gene in this region, In this study, we have identified a second region of LOH on 7q, at band 7q22. Deletion of genetic material at 7q22 was found in all tumor types and grades and was associated with increased tumor size. The region of LOH at 7q22 in every case included one or more of threepolymorphic markers that are located within the CUTL1 gene. LOH of 7q22 has also been documented in the case of human uterine leiomyomas (Zeng et al., 1997; Ishmad et al., 1997), Interestingly, in both leiomyomas and mammarytumors induced in transgenic mice expressing the Polyomavirus (PyV) large T (LT) antigen, immunocomplexes of CUTL1 and PyV LT antigen were detected (Webster et al., 1998), Altogether, genetic data in human breast cancer and biochemical analyses in breast tumors from transgenic mice suggest that CUTL1 is a candidate tumor suppressor gene.

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Documento generato il 30/05/20 alle ore 15:17:50