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Titolo:
Two-year changes in lipids and lipoproteins associated with the maintenance of a 5% to 10% reduction in initial weight: Some findings and some questions
Autore:
Wadden, TA; Anderson, DA; Foster, GD;
Indirizzi:
Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA
Titolo Testata:
OBESITY RESEARCH
fascicolo: 2, volume: 7, anno: 1999,
pagine: 170 - 178
SICI:
1071-7323(199903)7:2<170:TCILAL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-CALORIE DIET; CARDIOVASCULAR RISK-FACTORS; LONG-TERM; OBESITY TREATMENT; WOMEN; CHOLESTEROL; BENEFITS; PLASMA; MEN;
Keywords:
weight loss; cholesterol; triglycerides; low-calorie diets; females;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Wadden, TA UnivPAenn, Sch Med, Dept Psychiat, 3600 Market St,Suite 738, Philadelphia, Univ Penn 3600 Market St,Suite 738 Philadelphia PA USA 19104 a,
Citazione:
T.A. Wadden et al., "Two-year changes in lipids and lipoproteins associated with the maintenance of a 5% to 10% reduction in initial weight: Some findings and some questions", OBES RES, 7(2), 1999, pp. 170-178

Abstract

Objective: This study assessed whether a 5% to 10% reduction in initial weight would be associated with as favorable long-term (i.e., 100 weeks) changes in lipids and lipoproteins, as have been observed on a short-term basis(i.e., 8 weeks). Research Methods and Procedures: This was a prospective evaluation of 25 obese women, each of whom had lost greater than or equal to 5% of initial weight during 48 weeks of treatment and had maintained a weight loss of this magnitude at 1-year follow-up (week 100). Lipids and lipoproteins were obtained at baseline and at weeks 8, 24, 48, and 100. All participants had a baseline total cholesterol greater than or equal to 5.17 mmol/L (200 mg/dL). Results: At the end of the first 8 weeks, weight fell an average of 11.7+/-2.8%, total cholesterol 20.6+/-7.5%, low-density-lipoprotein (LDL) cholesterol 23.0+/-18.1%, and triglycerides 26.0+/-20.1%. At week 48, weight had fallen to 20.1+/-7.0% below baseline, but total cholesterol and LDL cholesterol were reduced only 11.5+/-10.4% and 12.0+/-14.0% below baseline, respectively. These latter reductions were significantly (p<0.05) smaller than those observed at week 8, despite the larger weight loss at week 48. High-density-lipoprotein cholesterol declined significantly values by week 24. Patients gained 7.4+/-7.4 kg from weeks 48 to 100, during which time total and LDL cholesterol (but not triglycerides) rose significantly (p<0.05). Patients who, at week 100, maintained losses >10% of initial weight had significantly greater reductions in total and LDL cholesterol values than did patients who maintained losses of only 5% to 10% of initial weight. Discussion: Results of this study underscore the importance of assessing long-term changes in weight-related health complications when patients have lost weight but are no longer dieting (and exercising) as aggressively as they did during the initial months of treatment.

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Documento generato il 05/12/20 alle ore 02:04:00