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Titolo:
Serum leptin in elderly people: Associations with sex hormones, insulin, and adipose tissue volumes
Autore:
Baumgartner, RN; Ross, RR; Waters, DL; Brooks, WM; Morley, JE; Montoya, GD; Garry, PJ;
Indirizzi:
Univ New Mexico, Sch Med, Clin Nutr Program,Ctr Populat Hlth, Dept Internal Univ New Mexico Albuquerque NM USA 87131 ,Ctr Populat Hlth, Dept Internal UnivAlbuquerque, Sch Med, Clin Nutr Program,Ctr Populat Hlth, Dept Pathol,Univ New Mexico Albuquerque NM USA 87131 m,Ctr Populat Hlth, Dept Pathol, Queens Univ, Dept Phys & Hlth Educ, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 Educ, Kingston, ON K7L 3N6, Canada Univ87131Mexico, Sch Med, Clin & Magnet Resonance Res Ctr, Albuquerque, NMUniv New Mexico Albuquerque NM USA 87131 sonance Res Ctr, Albuquerque, NM StUSAuis Univ, VA Med Ctr, Ctr Geriatr Res Educ & Clin, St Louis, MO 63104St Louis Univ St Louis MO USA 63104 r Res Educ & Clin, St Louis, MO 63104
Titolo Testata:
OBESITY RESEARCH
fascicolo: 2, volume: 7, anno: 1999,
pagine: 141 - 149
SICI:
1071-7323(199903)7:2<141:SLIEPA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; REPLACEMENT THERAPY; GENDER DIFFERENCES; FAT DISTRIBUTION; HYPOGONADAL MEN; OBESE HUMANS; BODY-FAT; IN-VIVO; HYPERINSULINEMIA; TESTOSTERONE;
Keywords:
leptin; body composition; sex hormones; insulin; elderly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Baumgartner, RN Univ New Mexico, Sch Med, Clin Nutr Program,Ctr Populat Hlth, Dept Internal Univ New Mexico 215 Surge Bldg Albuquerque NM USA 87131 al
Citazione:
R.N. Baumgartner et al., "Serum leptin in elderly people: Associations with sex hormones, insulin, and adipose tissue volumes", OBES RES, 7(2), 1999, pp. 141-149

Abstract

Objective: There are few data for associations of serum leptin with body fat, fat distribution, sex hormones, or fasting insulin in elderly adults. We hypothesized that the sex difference in serum leptin concentrations woulddisappear after adjustment for subcutaneous, but not visceral body fat. Serum leptin would not be associated with sex hormone concentrations or serumfasting insulin after adjusting for body fat and fat distribution. Research Methods and Procedures: Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volumes were measured using magnetic resonance imaging in a cross-sectional sample of 56 nondiabetic, elderly men and womenaged 64 years to 94 years. Serum leptin, sex hormones (testosterone and estrone), sex hormone-binding globulin, and fasting insulin were also measured. Nine women were taking hormone replacement, and five men were clinicallyhypogonadal. Results: Leptin was significantly associated with both SAT and VAT in eachsex. Adjustment for SAT reduced the sex difference in leptin by 56%, but adjustment for VAT increased the difference by 25%. Leptin was not associated with serum estrone or hormone replacement therapy in the women, but had asignificant, negative association with testosterone in the men that was independent of SAT, but not VAT. Leptin was significantly associated with fasting insulin in both sexes independent of age, sex hormones, sex hormone-binding globulin, VAT and SAT. Discussion: Sex difference in serum leptin is partly explained by different amounts of SAT. Studies including both men and women should adjust for SAT rather than total body fat that includes VAT. The sex difference in serumleptin is not due to estrogen, but may be partly explained by testosterone. Testosterone is negatively associated with leptin in men, but the association is confounded with VAT. Leptin is associated with fasting insulin in nondiabetic elderly men and women independent of body fat, fat distribution,or sex hormones.

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Documento generato il 05/07/20 alle ore 03:30:24