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Titolo:
Chronic oral haloperidol and clozapine in rats: A behavioral evaluation
Autore:
Schmitt, U; Dahmen, N; Fischer, V; Weigmann, H; Rao, ML; Reuss, S; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany Univ Mainz, Dept Anat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 ainz, Dept Anat, D-55131 Mainz, Germany Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 Bonn, Dept Psychiat, D-5300 Bonn, Germany
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 2, volume: 39, anno: 1999,
pagine: 86 - 91
SICI:
0302-282X(1999)39:2<86:COHACI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-FIELD BEHAVIOR; NEUROLEPTIC DRUGS; CLINICAL-RESPONSE; SCHIZOPHRENIA; AVOIDANCE; PLASMA; ANTIPSYCHOTICS; APOMORPHINE; PERFORMANCE; INHIBITION;
Keywords:
clozapine; haloperidol; chronical treatment; rat; behavior; locomotion; blood plasma levels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hiemke, C Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 ermany
Citazione:
U. Schmitt et al., "Chronic oral haloperidol and clozapine in rats: A behavioral evaluation", NEUROPSYCHB, 39(2), 1999, pp. 86-91

Abstract

The present study evaluated chronic oral treatment of rats with haloperidol or clozapine, Drugs were given in the drinking water for a 23-day period. Rat behavior was analyzed once a week in an open field. Rats ingested either 1.7 mg/kg haloperidol or 40 mg/kg clozapine daily. Blood serum analysis revealed concentrations of 6 ng/ml for haloperidol and 22 ng/ml for clozapine at the end of the treatment. Haloperidol decreased overall activity fromthe onset of treatment. Clozapine showed similar effects only on the last test day. Control animals showed a slight habituation in exploration-related parameters. In conclusion, these results indicate that oral drug administration through the drinking water is a suitable mode of noninvasive chronictreatment that led to sufficiently high drug levels to induce specific pharmacological effects in rats.

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Documento generato il 25/01/20 alle ore 19:12:56