Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEURAL ACTIVITY AFFECTS DISTRIBUTION OF GLUTAMATE RECEPTORS DURING NEUROMUSCULAR-JUNCTION FORMATION IN DROSOPHILA EMBRYOS
Autore:
SAITOE M; TANAKA S; TAKATA K; KIDOKORO Y;
Indirizzi:
GUNMA UNIV,SCH MED,INST BEHAV SCI,3-39-22 SHOWA MACHI MAEBASHI GUMMA 371 JAPAN GUNMA UNIV,SCH MED,INST MOL & CELLULAR REGULAT,DEPT CELL BIOL MAEBASHI GUMMA 371 JAPAN
Titolo Testata:
Developmental biology
fascicolo: 1, volume: 184, anno: 1997,
pagine: 48 - 60
SICI:
0012-1606(1997)184:1<48:NAADOG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINIC ACETYLCHOLINE-RECEPTORS; GENE-RELATED PEPTIDE; MUSCLE CULTURES; GROWTH CONES; MELANOGASTER; CLUSTERS; EXPRESSION; RELEASE; REDISTRIBUTION; EMBRYOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M. Saitoe et al., "NEURAL ACTIVITY AFFECTS DISTRIBUTION OF GLUTAMATE RECEPTORS DURING NEUROMUSCULAR-JUNCTION FORMATION IN DROSOPHILA EMBRYOS", Developmental biology, 184(1), 1997, pp. 48-60

Abstract

Changes in the distribution and density of transmitter receptors in the postsynaptic cell are required steps for functional synapse formation. We raised antibodies against Drosophila glutamate receptors (DGluR-II) and visualized the distribution of receptors during neuromuscularjunction formation in embryos. In wild-type embryos, embryonic development is complete within 22 hr after egg lying(AEL) and neuromuscular junction (NM) formation begins at 13 hr AEL. At the time of initial synapse formation, DGluR-IIs appeared as clusters closely associated with some muscle nuclei. Subsequently, these nonjunctional clusters dispersed while DGluR-IIs accumulated at the junctional region. In a paralytic temperature-sensitive mutant, para(ts1), neural activity decreasesdrastically at restrictive temperatures. When neural activity was blocked throughout synaptogenesis by rearing embryos at a restrictive temperature prior to the beginning of synaptogenesis, 12 hr AEL, the dispersal of extrajunctional clusters was significantly suppressed and no accumulation of receptors at the junction was observed at 22 hr AEL. However when neural activity was blocked later, by rearing embryos at arestrictive temperature from 13 hr AEL, DGluR-IIs did not accumulate at the NMJ, although extrajunctional clusters dispersed normally. These findings suggest that the neural activity differentially regulates dissipation of receptor clusters in the nonjunctional region and accumulation of receptors at the junctional region. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:13:29